Hiromi Kumon
Okayama University
Genetic enhancementCancerInternal medicineUrologySurgeryPathologyOncologyMolecular biologyChemistryProstatePseudomonas aeruginosaProstate cancerBladder cancerIn patientAntimicrobialCancer researchMedicineUrinary systemBiologyMicrobiology
627Publications
61H-index
7,823Citations
Publications 628
Newest
#1Kenji Araki (Okayama University)
Last. Hiromi Kumon (Okayama University)H-Index: 61
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Background/aim null The adenovirus vector- carrying reduced expression in immortalized cell (REIC) gene (Ad-REIC) increases endoplasmic reticulum stress chaperone GRP78/BiP expression and induces the JNK-mediated apoptotic pathway. We aimed to determine whether Ad-REIC-induced apoptotic cell death can trigger immunogenic cell death (ICD). null Materials and methods null We examined the emission of damage-associated molecular patterns in vitro and the vaccination effect in vivo. We determined the...
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Abstract null null The uncoupling protein 1 (UCP1) gene is known to be highly expressed in brown adipose tissue (BAT) that functions in thermogenesis. It has been shown that UCP1 mRNA is localized to the mouse adrenal gland, but its significance remains elusive. To explore how UCP1 expression in the adrenal gland is regulated, we generated a reporter knock-in mouse in which the GFP gene was inserted into the UCP1 locus using CRISPR-Cas9 system. Firstly, we confirmed by Western blot analysis UCP1...
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#1Yasuhiko HattoriH-Index: 5
Last. Yosuke ShimazuH-Index: 6
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#1Yuki Maruyama (Okayama University)H-Index: 4
#2Motoo Araki (Okayama University)H-Index: 17
Last. Hiromi Kumon (Okayama University)H-Index: 61
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BACKGROUND Long-term survival outcomes of patients who undergo endoscopic management of non-invasive upper tract urothelial carcinoma remain uncertain. The longest mean follow-up period in previous studies was 6.1 years. This study reports the long-term outcomes of patients with upper tract urothelial carcinoma who underwent ureteroscopic ablation at a single institution over a 28-year period. METHODS We identified all patients who underwent ureteroscopic management of upper tract urothelial car...
1 CitationsSource
#1Hirofumi Fujita (Okayama University)H-Index: 23
#2Tetsuya Bando (Okayama University)H-Index: 16
Last. Hideyo Ohuchi (Okayama University)H-Index: 56
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Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 ...
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#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Kentaro Fujii (Okayama University)H-Index: 8
Last. Isao Date (Okayama University)H-Index: 58
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Malignant glioma is one of the most common brain cancers in humans, which is very devastating. The expression of reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) is decreased in various human cancers. Lately, we have developed a novel second-generation adenoviral vector that expresses REIC/Dkk-3 (Ad-SGE-REIC) and revealed its antiglioma efficacy. The present investigator-initiated clinical trial is a single-arm, prospective, nonrandomized, noncomparative, open-label, single-cente...
3 CitationsSource
#1Emi Tanaka (Okayama University)H-Index: 3
#2Daisuke Uchida (Okayama University)H-Index: 10
Last. Hiroyuki Okada (Okayama University)H-Index: 62
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BACKGROUND: We previously demonstrated that the reduced expression in immortalized cells (REIC)/dikkopf-3 (Dkk-3) gene was downregulated in various malignant tumors, and that an adenovirus vector carrying the REIC/Dkk-3 gene, termed Ad-REIC induced cancer-selective apoptosis in pancreatic cancer and hepatocellular carcinoma. OBJECTIVE: In this study, we examined the therapeutic effects of Ad-REIC in biliary cancer using a second-generation Ad-REIC (Ad-SGE-REIC). METHODS: Human biliary cancer cel...
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#1Munenori Habuta (Okayama University)H-Index: 2
#2Hirofumi Fujita (Okayama University)H-Index: 23
Last. Hideyo Ohuchi (Okayama University)H-Index: 56
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REIC (reduced expression in immortalized cells) has been identified as a gene whose expression was reduced in immortalized cultured cells. The REIC gene is identical to Dickkopf-3 (Dkk3), which encodes a secreted glycoprotein belonging to the Dkk family. Previously, we showed that Dkk3 protein is present in the mouse adrenal medulla. However, its role in this tissue has not been elucidated. To explore it, we performed electron microscopic (EM) studies and RNA-sequencing (RNA-seq) analysis on Dkk...
2 CitationsSource
#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2K. Fujii (Okayama University)H-Index: 2
Last. Isao Date (Okayama University)H-Index: 58
view all 11 authors...
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#1Astushi Oyama (Okayama University)H-Index: 1
#2Hidenori Shiraha (Okayama University)H-Index: 26
Last. Hiromi Kumon (Okayama University)H-Index: 61
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: This study will assess the safety and efficacy of the administration of adenoviral vector expressing the human-reduced expression in immortalized cells (Ad-REIC) to a liver tumor in patients with hepatocellular carcinoma (HCC) or liver metastasis of pancreatic cancer. A Phase I clinical study of Ad-REIC administration to a liver tumor in a patient with HCC or liver metastasis of pancreatic cancer will be conducted. The study is a single-arm, prospective, nonrandomized, noncomparative, open-lab...
2 CitationsSource