Eric L. Harshfield
University of Cambridge
GeneGenome-wide association studyEpidemiologyInternal medicineOdds ratioGenetic associationGenomicsCoronary artery diseaseDementiaMendelian randomizationBody mass indexPopulationMendelian Randomization AnalysisCoronary heart diseaseLipid metabolismRisk factorStrokeLipidomicsGenetic predispositionComputational biologyMedicineBiologyEnvironmental health
29Publications
10H-index
384Citations
Publications 26
Newest
#1Eric L. Harshfield (University of Cambridge)H-Index: 10
#2Sands Cj (Imperial College London)
Last. Hugh S. Markus (University of Cambridge)H-Index: 131
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Cerebral small vessel disease (SVD) is a major cause of vascular cognitive impairment and dementia. There are few treatments, largely reflecting limited understanding of the underlying pathophysiology. Metabolomics can be used to identify novel risk factors in order to better understand pathogenesis and to predict disease progression and severity. We analysed data from 624 patients with symptomatic cerebral SVD from two prospective cohort studies. Serum samples were collected at baseline and pat...
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#1Bernard P H Cho (University of Cambridge)H-Index: 1
#2Stefania Nannoni (University of Cambridge)H-Index: 8
Last. Hugh S. Markus (University of Cambridge)H-Index: 131
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BACKGROUND Cysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), have been reported more common than expected in the general population, but their clinical significance and contribution to stroke and dementia risk in the community remain unclear. METHODS Cysteine-altering NOTCH3 variants were identified in UK Biobank whole-exome sequencing data (N=200 63...
2 CitationsSource
#1Eric L. Harshfield (University of Cambridge)H-Index: 10
#2Marios K. Georgakis (LMU: Ludwig Maximilian University of Munich)H-Index: 19
Last. Hugh S. Markus (University of Cambridge)H-Index: 131
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Background and Purpose: Assessing whether modifiable risk factors are causally associated with stroke risk is important in planning public health measures, but determining causality can be difficul...
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#1Marios K. Georgakis (LMU: Ludwig Maximilian University of Munich)H-Index: 19
#2Eric L. Harshfield (University of Cambridge)H-Index: 10
Last. M Dichgans (LMU: Ludwig Maximilian University of Munich)H-Index: 7
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Objective: We employed Mendelian randomization (MR) to explore the effects of genetic predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and β-cell dysfunction on risk of stroke subtypes and related cerebrovascular phenotypes. Methods: We selected instruments for genetic predisposition to T2D (74,124 cases, 824,006 controls), HbA1c levels (n=421,923), fasting glucose levels (n=133,010), insulin resistance (n=108,557), and β-cell dysfunction (n=16,378) based on published ...
2 CitationsSource
#1Eric L. Harshfield (University of Cambridge)H-Index: 10
#2Lisa Pennells (University of Cambridge)H-Index: 16
Last. Karina W. DavidsonH-Index: 89
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Importance It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs). Objective To characterize the association between depressive symptoms and CVD incidence across the spectrum of lower mood. Design, setting, and participants A pooled analysis of individual-participant data from the Emerging Risk Factors Collaboration (ERFC; 162 036 participants; 21 cohorts; baseline surveys, 1960-2008; latest follow-up, March 2020) and the U...
6 CitationsSource
#1Bernard Ph Cho (University of Cambridge)H-Index: 1
#2Stefania Nannoni (University of Cambridge)H-Index: 8
Last. Hugh S. Markus (University of Cambridge)H-Index: 131
view all 7 authors...
BackgroundCysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL, have been reported more common than expected in the general population, but their clinical significance and contribution to stroke and dementia risk in the community remains unclear. MethodsCysteine-altering NOTCH3 variants were identified in UK Biobank whole-exome sequencing data (N=200,632). Frequency of stroke, dementia and other clinical features of CADASIL, and MRI white matter...
1 CitationsSource
#1Eric L. HarshfieldH-Index: 10
#2Eric B. Fauman (Pfizer)H-Index: 26
Last. Albert Koulman (NIHR: National Institute for Health Research)H-Index: 4
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ABSTRACT Background Genetic, lifestyle, and environmental factors can lead to perturbations in circulating lipid levels and increase risk of cardiovascular and metabolic diseases. However, how changes in individual lipid species contribute to disease risk is often unclear. Moreover, little is known about the role of lipids on cardiovascular disease in Pakistan, a population historically underrepresented in cardiovascular studies. Methods We characterised the genetic architecture of the human blo...
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#1Steven Bell (University of Cambridge)H-Index: 21
#2Joel T. Gibson (University of Cambridge)H-Index: 1
Last. Hugh S. Markus (University of Cambridge)H-Index: 131
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Abstract Background and aims Observational studies have reported an association between periodontitis and cardiovascular disease but whether this association is causal is uncertain. We therefore used Mendelian randomization to test whether periodontitis is causally associated with stroke, coronary artery disease, or subclinical atherosclerosis. Methods A two-sample Mendelian randomisation analysis was carried out using five single nucleotide polymorphisms previously associated with periodontitis...
2 CitationsSource
#1Eric L. Harshfield (University of Cambridge)H-Index: 10
#2Matthew C. Sims (University of Cambridge)H-Index: 4
Last. Hugh S. Markus (University of Cambridge)H-Index: 131
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This study was supported by a British Heart Foundation Programme grant (RG/16/4/32218) and the European Union’s Horizon 2020 research and innovation programme under grant agreement No 667375 (CoSTREAM). It also received infrastructural support from the Cambridge University Hospitals NIHR Biomedical Research Centre. This research was conducted using the UK Biobank resource (application 36509). The MEGASTROKE project received funding from sources specified at http://megastroke.org/acknowledgements...
9 CitationsSource
#1Hugh S. Markus (University of Cambridge)H-Index: 131
#2Eric L. Harshfield (University of Cambridge)H-Index: 10
Last. S WuppalapatiH-Index: 4
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BACKGROUND: Symptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. Vertebral artery stenosis can be treated with stenting with good technical results, but whether it results in improved clinical outcome is uncertain. We aimed to compare vertebral stenting with medical treatment for symptomatic vertebral stenosis. METHODS: We did a preplanned pooled individual patient data analysis of three compl...
10 CitationsSource