Henriette Frikke-Schmidt
University of Michigan
Gene silencingInternal medicineEndocrinologyLipolysisSurgeryTaste aversionIsletReceptorAdipose tissueChemistryIn vivoArea postremaInflammationHindbrainType 2 diabetesCholesterolSleeve gastrectomyPancreasInsulinVitamin CLiraglutideVitamin C deficiencyMouse PancreasPreclinical imagingAscorbic acidInsulin secretionFood intakeGastric emptyingLipid metabolismSecretionWeight lossBiochemistryHomeostasisMedicineBiology
23Publications
11H-index
359Citations
Publications 21
Newest
#1Paul V. Sabatini (UM: University of Michigan)H-Index: 8
#2Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
Last. Randy J. Seeley (UM: University of Michigan)H-Index: 111
view all 13 authors...
The TGFβ cytokine family member, GDF-15, reduces food intake and body weight and represents a potential treatment for obesity. Because the brainstem-restricted expression pattern of its receptor, GDNF Family Receptor α–like (GFRAL), presents an exciting opportunity to understand mechanisms of action for area postrema neurons in food intake; we generated GfralCre and conditional GfralCreERT mice to visualize and manipulate GFRAL neurons. We found infection or pathophysiologic states (rather than ...
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#1Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
#2Peter Arvan (UM: University of Michigan)H-Index: 29
Last. Corentin Cras-Méneur (UM: University of Michigan)H-Index: 23
view all 4 authors...
While numerous techniques can be used to measure and analyze insulin secretion in isolated islets in culture, assessments of insulin secretion in vivo are typically indirect and only semiquantitative. The CpepSfGFP reporter mouse line allows the in vivo imaging of insulin secretion from individual islets after a glucose stimulation, in live, anesthetized mice. Imaging the whole pancreas at high resolution in live mice to track the response of each individual islet over time includes numerous tec...
2 CitationsSource
#1Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
#2Peter Arvan (UM: University of Michigan)H-Index: 29
Last. Corentin Cras-Méneur (UM: University of Michigan)H-Index: 23
view all 4 authors...
While numerous techniques can be used to measure and analyze insulin secretion in isolated islets in culture, assessments of insulin secretion in vivo are typically indirect and only semiquantitative. The CpepSfGFP reporter mouse line allows the in vivo imaging of insulin secretion from individual islets after a glucose challenge, in live, anesthetized mice, addressing secretion from the pancreas as a whole. Imaging the whole pancreas at high resolution in live mice includes numerous technical c...
Source
#1Paul V. Sabatini (UM: University of Michigan)H-Index: 8
#2Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
Last. Randy J. Seeley (UM: University of Michigan)H-Index: 111
view all 12 authors...
To determine the function and mechanisms of action for hindbrain neurons that express GFRAL, the receptor for the anorexigenic peptide, GDF-15, we generated GfralCre and conditional GfralCreERT mice. While signals of infection or pathophysiologic states (rather than meal ingestion) stimulate GFRAL neurons, the artificial activation of GfralCre-expressing neurons inhibited feeding, decreased gastric emptying, and promoted a conditioned taste aversion (CTA). Additionally, activation of the smaller...
Source
#1Paul V. Sabatini (UM: University of Michigan)H-Index: 8
#2Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
Last. Randy J. Seeley (UM: University of Michigan)H-Index: 111
view all 6 authors...
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#1Wenwen Cheng (UM: University of Michigan)H-Index: 3
#2Ian E. Gonzalez (UM: University of Michigan)H-Index: 5
Last. Martin G. MyersH-Index: 100
view all 22 authors...
Summary To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists. Similarly, activating CalcrNTS neurons decreased food intake and body weight but (unlike neighboring CckNTS cells) failed to promote aversion, revealing that CalcrNTS neurons mediate a non-aversive suppression of food...
21 CitationsSource
Last. Randy J. SeeleyH-Index: 111
view all 4 authors...
Glucagon-like peptide-1 (GLP-1) is an incretin, secreted in response to a meal that promotes glucose-stimulated insulin secretion in animal models and diabetic and nondiabetic humans. GLP-1 analogues have been successfully used as an effective treatment for both obesity and type 2 diabetes. While the general mechanisms of actions of GLP-1 on β-cell growth and function have been extensively studied, a number of questions regarding the dynamic and heterogeneity of the response of individual islets...
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#1Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
#2Karin Hultman (Novo Nordisk)H-Index: 11
Last. Randy J. Seeley (UM: University of Michigan)H-Index: 111
view all 6 authors...
Abstract Objective Analogues of GDF15 (Growth Differentiation Factor 15) are promising new anti-obesity therapies as pharmacological treatment with GDF15 results in dramatic reductions of food intake and body weight. GDF15 exerts its central anorexic effects by binding to the GFRAL receptor exclusively expressed in the Area Postrema (AP) and the Nucleus of the Solitary Tract (NTS) of the hindbrain. We sought to determine if GDF15 is an indispensable factor for other interventions that cause weig...
18 CitationsSource
#1Deanna M. Arble (UM: University of Michigan)H-Index: 13
#2Simon S. Evers (UM: University of Michigan)H-Index: 9
Last. Randy J. Seeley (UM: University of Michigan)H-Index: 111
view all 8 authors...
Abstract Background One-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (SG) are limited. Objectives To examine the metabolic outcomes of OAGB, SADS, RYGB, and SG in a controlled rodent model. Setting Academic research laboratory, United States. Methods Surgeries were pe...
9 CitationsSource
#1Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
#2Brian F. Zamarron (UM: University of Michigan)H-Index: 16
Last. Randy J. Seeley (UM: University of Michigan)H-Index: 111
view all 6 authors...
Abstract Objective In addition to adipocytes, adipose tissue contains large numbers of immune cells. A wide range of evidence links the activity of these cells to regulation of adipocyte and systemic metabolic function. Bariatric surgery improves several aspects of metabolic derangements and at least some of these effects occur in a weight-loss independent manner. We sought to investigate the impact of vertical sleeve gastrectomy (VSG) on adipose immune cell frequencies. Methods We analyzed the ...
16 CitationsSource