Katsuya Hirasaka
Nagasaki University
AnatomyInternal medicineEndocrinologyUbiquitin ligaseGene expressionMolecular biologyChemistryImmunologyMyocyteMuscle atrophyDenervationSkeletal muscleAtrophyMitochondrionFood scienceMyogenesisReactive oxygen speciesBiochemistryMedicineBiologyCell biology
109Publications
21H-index
1,559Citations
Publications 109
Newest
#1Min Yang (Nagasaki University)H-Index: 3
#2Luchuanyang Sun (Nagasaki University)H-Index: 1
Last. Katsuya Hirasaka (Nagasaki University)H-Index: 21
view all 9 authors...
Balenine is one of the endogenous imidazole dipeptides, mainly found in the muscle of marine animals. In this study we focused on the safety evaluation and physiological function of dietary balenine derived from opah Lampris guttatus in skeletal muscle of mice. There were no significant differences among different concentrations (0–1%) of balenine diet in the basic data included the weight of body weight, food intake, skeletal muscle and some organs, indicating that less than 1% dietary balenine...
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#1Kosuke Sugiura (University of Tokushima)H-Index: 5
#2Katsuya Hirasaka (Nagasaki University)H-Index: 21
Last. Reiko Nakao (University of Tokushima)H-Index: 14
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Recent studies show that muscle mass and metabolic function are interlinked. Muscle RING finger 1 (MuRF1) is a critical muscle-specific ubiquitin ligase associated with muscle atrophy. Yet, the molecular target of MuRF1 in atrophy and aging remains unclear. We examined the role of MuRF1 in aging, using MuRF1-deficient (MuRF1-/- ) mice in vivo, and MuRF1-overexpressing cell in vitro. MuRF1 deficiency partially prevents age-induced skeletal muscle loss in mice. Interestingly, body weight and fat m...
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#1Min Yang (Nagasaki University)H-Index: 3
#2Luchuanyang Sun (Nagasaki University)H-Index: 1
Last. Katsuya Hirasaka (Nagasaki University)H-Index: 21
view all 7 authors...
Balenine is one of the endogenous imidazole dipeptides. It is composed of beta-alanine and 3-methyl-l-histidine, which exist mainly in the muscles and the brain. The exact biological properties of balenine are still not well known, although the antioxidant activity of carnosine, another imidazole dipeptide, is known. In this study we investigated whether balenine exhibits antioxidant activity. It was found to decrease the superoxide anion (O2−) and increased hydrogen peroxide (H2O2) generation. ...
2 CitationsSource
#1Anayt Ulla (University of Tokushima)
#2Takayuki Uchida (University of Tokushima)H-Index: 7
Last. Takeshi Nikawa (University of Tokushima)H-Index: 33
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Abstract Glucocorticoids are the drugs most commonly used to manage inflammatory diseases. However, they are prone to inducing muscle atrophy by increasing muscle proteolysis and decreasing protein synthesis. Various studies have demonstrated that antioxidants can mitigate glucocorticoid-induced skeletal muscle atrophy. Here, we investigated the effect of a potent antioxidative natural flavonoid, morin, on the muscle atrophy and oxidative stress induced by dexamethasone (Dex) using mouse C2C12 s...
1 CitationsSource
#1Yan Liang (Nagasaki University)H-Index: 2
#2Shijiao Zha (Nagasaki University)H-Index: 2
Last. Tatsuya Oda (Nagasaki University)H-Index: 44
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In this study, we found that a sulfated polysaccharide isolated from the brown alga Ascophyllum nodosum, ascophyllan, showed suppressive effects on stimulated RAW264.7 cells. Ascophyllan significantly inhibited expression of inducible nitric oxide synthase mRNA and excessive production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells in a dose-dependent manner without affecting the viability of RAW264.7 cells. Ascophyllan also reduced the elevated level of intracellular...
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#1Luchuanyang SunH-Index: 1
Last. Katsuya HirasakaH-Index: 21
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Astaxanthin (AX) is a carotenoid that exerts potent antioxidant activity and acts in the lipid bilayer. This study aimed to investigate the effects of AX on muscle-atrophy-mediated disturbance of mitochondria, which have a lipid bilayer. Tail suspension was used to establish a muscle-atrophied mouse model. AX diet fed to tail-suspension mice prevented loss of muscle weight, inhibited the decrease of myofiber size, and restrained the increase of hydrogen peroxide (H2O2) production in the soleus m...
1 CitationsSource
#1Yao Wang (Nagasaki University)H-Index: 4
#2Jia Liang (ZJOU: Zhejiang Ocean University)H-Index: 2
Last. Shigeto Taniyama (Nagasaki University)H-Index: 14
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We previously showed that the tenderization of ordinary muscle during ice storage is affected by the interposition of pink muscle fibers in the ordinary muscle. However, little is known about whether or not the interposition of pink muscle fibers affects the hardness of raw fish meat. To clarify the influence of the interposition of pink muscle fibers in the dorsal ordinary muscle on hardness of meat, the breaking strengths and the fiber types of the dorsal ordinary muscle of eight fish species ...
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#1Seiji Takeuchi (Nagasaki University)H-Index: 6
#2Kohei Honma (Nagasaki University)
Last. Katsuya Hirasaka (Nagasaki University)H-Index: 21
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#1Takasi OkimuraH-Index: 11
#2Zedong Jiang (JMU: Jimei University)H-Index: 17
Last. Tatsuya Oda (Nagasaki University)H-Index: 44
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Abstract Ascophyllan HS is a commercially available preparation of the edible brown alga Ascophyllum nodosum containing ascophyllan, a sulfated polysaccharide with diverse beneficial biological activities. In this study, the effects of ascophyllan HS were evaluated in a severe intranasal Streptococcus pneumoniae infection mouse model. The control untreated mice started to die on day 7 and 80% had died by day 14 post-infection. Continuous oral administration of ascophyllan HS before and after bac...
4 CitationsSource
#1Luchuanyang SunH-Index: 1
Last. Katsuya HirasakaH-Index: 21
view all 11 authors...
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