Nancy J. Philp
Thomas Jefferson University
Internal medicineEndocrinologyFunction (biology)Membrane proteinTransporterMolecular biologyChemistryGlycolysisRetinaGLUT1Retinal pigment epitheliumRetinalMonocarboxylate transporterLactate transportEpithelial polarityCancer researchBiochemistryAnaerobic glycolysisOxidative phosphorylationMetabolismCell cultureBiologyCell biology
Publications 89
#1Paul G. FitzGerald (UC Davis: University of California, Davis)H-Index: 30
#2Nancy J. Philp (Thomas Jefferson University)H-Index: 37
#1christopher Sutera (PCOM: Philadelphia College of Osteopathic Medicine)
#2Rushil Brahmbhatt (PCOM: Philadelphia College of Osteopathic Medicine)
Last. Janine Tsai (PCOM: Philadelphia College of Osteopathic Medicine)
view all 15 authors...
#1S. Hamad Sagheer (Thomas Jefferson University)
#2Diana Whitaker-Menezes (Thomas Jefferson University)H-Index: 51
Last. Nancy J. Philp (Thomas Jefferson University)H-Index: 37
view all 6 authors...
Abstract Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck cancer, with a 5-year survival rate of only 50%. There is a pressing need for animal models that recapitulate the human disease to understand the factors driving OSCC carcinogenesis. Many laboratories have used the chemical carcinogen 4-nitroquinoline-1-oxide (4NQO) to investigate OSCC formation. The importance of the 4NQO mouse model is that it mimics the stepwise progression observed in OSCC patients. The ...
#1Nikolai P. Skiba (Duke University)H-Index: 25
#2Martha A. Cady (Duke University)H-Index: 3
Last. Vadim Y. Arshavsky (Duke University)H-Index: 54
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Abstract The outer segment (OS) organelle of vertebrate photoreceptors is a highly specialized cilium evolved to capture light and initiate light response. The plasma membrane which envelopes the outer segment plays vital and diverse roles in supporting photoreceptor function and health. However, little is known about the identity of its protein constituents, as this membrane cannot be purified to homogeneity. In this study, we employed the technique of protein correlation profiling to identify ...
1 CitationsSource
#1John Y. S. Han (Thomas Jefferson University)H-Index: 3
#2Junzo Kinoshita (Cleveland Clinic)H-Index: 4
Last. Nancy J. Philp (Thomas Jefferson University)H-Index: 37
view all 7 authors...
The neural retina metabolizes glucose through aerobic glycolysis generating large amounts of lactate. Lactate flux into and out of cells is regulated by proton-coupled monocarboxylate transporters (MCTs), which are encoded by members of the Slc16a family. MCT1, MCT3, and MCT4 are expressed in the retina and require association with the accessory protein basigin, encoded by Bsg, for maturation and trafficking to the plasma membrane. Bsg(-/-) mice have severely reduced electroretinograms (ERGs) an...
8 CitationsSource
#1Elizabeth S. Silagi (Thomas Jefferson University)H-Index: 8
#2Emanuel J. Novais (Thomas Jefferson University)H-Index: 4
Last. Makarand V. Risbud (Thomas Jefferson University)H-Index: 64
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Maintenance of glycolytic metabolism is postulated to be required for health of the spinal column. In the hypoxic tissues of the intervertebral disc and glycolytic cells of vertebral bone, glucose is metabolized into pyruvate for ATP generation and reduced to lactate to sustain redox balance. The rise in intracellular H+ /lactate concentrations are balanced by plasma-membrane monocarboxylate transporters (MCTs). Using MCT4 null mice and human tissue samples, complimented with genetic and metabol...
15 CitationsSource
#1Aparna Lakkaraju (UCSF: University of California, San Francisco)H-Index: 20
#2Ankita Umapathy (UCLA: University of California, Los Angeles)H-Index: 2
Last. David S. Williams (UCLA: University of California, Los Angeles)H-Index: 75
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Abstract The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness. Decades of research have yielded valuable insight into the cell biology of the RPE. In recent years, new approaches, including new technologies, such as live-cell im...
46 CitationsSource
#1Sara Bisetto (Thomas Jefferson University)H-Index: 8
#2Megan C. Wright (Arcadia University)H-Index: 14
Last. Nancy J. Philp (Thomas Jefferson University)H-Index: 37
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Summary Lactate produced by muscle during high intensity activity is an important end product of glycolysis that supports whole body metabolism. The lactate shuttle model suggested that lactate produced by glycolytic muscle fibers is utilized by oxidative fibers. MCT4 is a proton coupled monocarboxylate transporter preferentially expressed in glycolytic muscle fibers and facilitates the lactate efflux. Here we investigated the exercise capacity of mice with disrupted lactate shuttle due to globa...
7 CitationsSource
#1Lauren L. Daniele (UPenn: University of Pennsylvania)H-Index: 11
#2Jennifer Caughey (UPenn: University of Pennsylvania)H-Index: 3
Last. Kathleen Boesze-Battaglia (UPenn: University of Pennsylvania)H-Index: 35
view all 8 authors...
The retinal pigment epithelium (RPE) supports the outer retina through essential roles in the retinoid cycle, nutrient supply, ion exchange and waste removal. Each day the RPE removes the oldest ~1...
4 CitationsSource
#1Ayan Kumar (Thomas Jefferson University)H-Index: 5
#2Alexander Knops (Thomas Jefferson University)H-Index: 2
Last. Joseph Curry (Thomas Jefferson University)H-Index: 22
view all 11 authors...
Background: Head and neck squamous cell carcinoma (HNSCC) exists within a microenvironment rich in immune cells. Macrophages are particularly abundant in and around tumor tissue, and have been implicated in the growth, malignancy, and persistence of HNSCC [1]. However, current literature reports variable degrees of association between the density of tumor-associated macrophages (TAMs) and clinicopathologic markers of disease [2,3]. These inconsistent findings may be a result of differences in ap...
34 CitationsSource