Robert E. Shaddy
Children's Hospital Los Angeles
Internal medicineSurgeryAntibodyCardiologyRetrospective cohort studyIntensive care medicinePediatricsImmunologyDilated cardiomyopathyHeart failureCardiomyopathyHeart transplantationVentricleDiseaseStenosisHeart diseaseMyocarditisPopulationTransplantationPediatric heart transplantationAnesthesiaClinical trialMedicine
283Publications
53H-index
6,823Citations
Publications 268
Newest
#1Karla L. Loss (Children's Hospital Los Angeles)
#2Robert E. Shaddy (Children's Hospital Los Angeles)H-Index: 53
Last. Paul F. Kantor (Children's Hospital Los Angeles)H-Index: 5
view all 3 authors...
Pediatric heart failure (HF) is an important clinical condition with high morbidity, mortality and costs. Due to the heterogeneity in clinical presentation and etiologies, the development of therapeutic strategies is more challenging in children than adults. Most guidelines recommending drug therapy for pediatric HF are extrapolated from studies in adults. Unfortunately, even using all available treatment, progression to cardiac transplantation is common. The development of prospective clinical ...
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Background In adults with heart failure, elevated heart rate is associated with lower survival. We determined whether an elevated heart rate was associated with an increased risk of death or heart ...
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#1William T. MahleH-Index: 64
#2Kristen L. MasonH-Index: 3
Last. Ctotc InvestigatorsH-Index: 2
view all 16 authors...
: The frequency, indications, and outcomes for readmission following pediatric heart transplantation are poorly characterized. A better understanding of this phenomenon will help guide strategies to address the causes of readmission. Data from the Clinical Trials in Organ Transplantation for Children (CTOTC-04) multi-institutional collaborative study were utilized to determine incidence of, and risk factors for, hospital readmission within 30 days and 1 year from initial hospital discharge. Amon...
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#1Jacqueline M. Lamour (Boston Children's Hospital)H-Index: 24
#2Kristen L. MasonH-Index: 3
Last. Ctotc InvestigatorsH-Index: 2
view all 19 authors...
BACKGROUND Immunosuppression strategies have changed over time in pediatric heart transplantation. Thus, comorbidity profiles may have evolved. Clinical Trials in Organ Transplantation in Children-04 is a multicenter, prospective, cohort study assessing the impact of pre-transplant sensitization on outcomes after pediatric heart transplantation. This sub-study reports 1-year outcomes among recipients without pre-transplant donor-specific antibodies (DSAs). METHODS We recruited consecutive candid...
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#2Robert E. Shaddy (Children's Hospital Los Angeles)H-Index: 53
Last. Paul F. Kantor (Children's Hospital Los Angeles)H-Index: 5
view all 3 authors...
Purpose of reviewThis review highlights recent advances in the diagnosis and management of children with heart failure. We emphasize the clinical approach to patient care in the areas of acute decompensated heart failure, chronic heart failure, and failure of the patient with single ventricle physio
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#1William T. MahleH-Index: 64
#2Kristen L. MasonH-Index: 3
Last. Steven A. Webber (Vandy: Vanderbilt University)H-Index: 67
view all 14 authors...
Purpose The frequency, indications and outcomes for readmission following pediatric heart transplantation are poorly characterized. A better understanding of this phenomenon will help guide strategies to address the causes of readmission. Methods Data from the Clinical Trials in Organ Transplantation for Children (CTOTC-04) multi-institutional collaborative study were utilized to determine the incidence of, and risk factors for, hospital readmission within 30 days and 1 year from initial hospita...
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ABSTRACTIntroduction: Unlike the adult heart failure (HF) patient population, there is scarce information on the overall burden of HF in the pediatric population across geographies and within diffe...
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#1Danielle S. Burstein (Children's Hospital of Philadelphia)H-Index: 7
#2Pirouz Shamszad (Children's Hospital of Philadelphia)H-Index: 7
Last. Joseph W. Rossano (Children's Hospital of Philadelphia)H-Index: 44
view all 10 authors...
Background Children with congenital heart disease (CHD) are at risk for advanced heart failure (AHF). We sought to define the mortality and resource utilization in CHD-related AHF in children and young adults. Methods All hospitalizations in the Pediatric Health Information System database involving patients ≤21 years old with a CHD diagnosis and heart failure requiring at least 7 days of continuous inotropic support between 2004 and 2015 were included. Hospitalizations including CHD surgery wer...
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#1Steven A. Webber (Vandy: Vanderbilt University)H-Index: 67
#2A. Zeevi (University of Pittsburgh)H-Index: 33
Last. Ctotc InvestigatorsH-Index: 2
view all 17 authors...
: Sensitization is common in pediatric heart transplant candidates and waitlist mortality is high. Transplantation across a positive crossmatch may reduce wait time, but is considered high risk. We prospectively recruited consecutive candidates at eight North American centers. At transplantation, subjects were categorized as nonsensitized or sensitized (presence of ≥1 HLA antibody with MFI ≥1000 using single antigen beads). Sensitized subjects were further classified as complement-dependent cyto...
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#1Anne I. Dipchand (U of T: University of Toronto)H-Index: 57
#2S. Webber (VUMC: Vanderbilt University Medical Center)H-Index: 1
Last. A. Zeevi (University of Pittsburgh)H-Index: 33
view all 18 authors...
: Data on the clinical importance of newly detected donor-specific anti-HLA antibodies (ndDSAs) after pediatric heart transplantation are lacking despite mounting evidence of the detrimental effect of de novo DSAs in solid organ transplantation. We prospectively tested 237 pediatric heart transplant recipients for ndDSAs in the first year posttransplantation to determine their incidence, pattern, and clinical impact. One-third of patients developed ndDSAs; when present, these were mostly detecte...
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