Krista F. Huybrechts
Brigham and Women's Hospital
PsychiatryInternal medicineObstetricsOdds ratioIntensive care medicinePropensity score matchingPediatricsEmergency medicineCohort studyPharmacoepidemiologyMedical prescriptionMedicaidPregnancyMEDLINEPopulationConfidence intervalMedicineCohortConfoundingRelative risk
226Publications
53H-index
6,139Citations
Publications 212
Newest
#1Sonia Hernandez-Diaz (Harvard University)H-Index: 82
#2Brian T. Bateman (Brigham and Women's Hospital)H-Index: 65
Last. Krista F. Huybrechts (Brigham and Women's Hospital)H-Index: 53
view all 7 authors...
We assessed the teratogenicity of tenofovir, a human immunodeficiency virus (HIV) drug similar to remdesivir currently being evaluated for the treatment of coronavirus disease 2019 (COVID-19). Using US Medicaid Analytic Extract (MAX) claims data (2000-2014), we identified a population-based pregnancy cohort of women with HIV who filled ≥1 prescription for antiretroviral therapies (ART) during the first trimester. Women on tenofovir disoproxil fumarate (TDF) were compared with women receiving ART...
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#1Brian Shiner (Veterans Health Administration)H-Index: 21
#2Jenna Forehand (Veterans Health Administration)H-Index: 3
Last. Jaimie L. Gradus (BU: Boston University)H-Index: 26
view all 12 authors...
ABSTRACT null null Background null Despite the prevalence and negative impact of posttraumatic stress disorder (PTSD), there are few medications approved by the United States Food and Drug Administration (FDA) for treatment, and approved medications do not work well enough. We leveraged large-scale electronic health record data to identify existing medications that may be repurposed as PTSD treatments. null null null Methods null We constructed a mechanistic tree of all FDA-approved medications ...
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#1Loreen Straub (Brigham and Women's Hospital)H-Index: 5
#2Brian T. Bateman (Brigham and Women's Hospital)H-Index: 65
Last. Clara Hildebrandt (Boston Children's Hospital)H-Index: 4
view all 23 authors...
PURPOSE To validate healthcare claim-based algorithms for neurodevelopmental disorders (NDD) in children using medical records as the reference. METHODS Using a clinical data warehouse of patients receiving outpatient or inpatient care at two hospitals in Boston, we identified children (≤14 years between 2010 and 2014) with at least one of the following NDDs according to claims-based algorithms: autism spectrum disorder/pervasive developmental disorder (ASD), attention deficit disorder/other hyp...
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#1Loreen Straub (Brigham and Women's Hospital)H-Index: 5
#2Krista F. Huybrechts (Brigham and Women's Hospital)H-Index: 53
Last. Brian T. Bateman (Brigham and Women's Hospital)H-Index: 65
view all 8 authors...
Little is known about the impact of dose, duration and timing of prenatal prescription opioid exposure on the risk of neonatal opioid withdrawal syndrome (NOWS). Using a cohort of 18,869 pre-pregnancy chronic opioid users nested in the 2000-2014 Medicaid Analytic eXtract, we assessed average opioid dosage within bi-weekly gestational age intervals, created group-based trajectory models and evaluated the association between trajectory groups and NOWS risk. Women were grouped into 6 distinct traje...
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#1Alejandro Szmulewicz (Harvard University)H-Index: 12
#2Brian T. Bateman (Brigham and Women's Hospital)H-Index: 65
Last. Krista F. Huybrechts (Brigham and Women's Hospital)H-Index: 53
view all 4 authors...
The US FDA issued a black-box warning against co-prescription of antipsychotic (AP) agents and opioids due to the risk of respiratory depression, but evidence on the comparative safety of sedating vs nonsedating APs is lacking. We classified APs as sedating (eg, quetiapine, olanzapine, and chlorpromazine) and nonsedating (eg, aripiprazole, haloperidol, and risperidone) based on their affinity to the histamine-1 neuroreceptor (Ki < or ≥20, respectively) and sought to compare the rate of overdose ...
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#1Daina B. Esposito (BU: Boston University)H-Index: 10
#2Brian T. Bateman (Brigham and Women's Hospital)H-Index: 65
Last. Krista F. Huybrechts (Brigham and Women's Hospital)H-Index: 53
view all 7 authors...
Source
#1Gabriella Bröms (KI: Karolinska Institutet)H-Index: 11
#2Sonia Friedman (Brigham and Women's Hospital)H-Index: 25
Last. Rishi J. Desai (Brigham and Women's Hospital)H-Index: 30
view all 9 authors...
Background Population-level data spanning different countries describing oral and parenteral treatment in pregnant women with inflammatory bowel disease (IBD) are scarce. We studied treatment with sulfasalazine/5-aminosalicylates, corticosteroids, thiopurines/immunomodulators, and tumor necrosis factor (TNF)-inhibitors in the United States (Optum Clinformatics Data Mart and the Medicaid Analytics Extract [MAX]) and in the Swedish national health registers. Methods We identified 2975 pregnant wom...
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#1Mollie Wood (Harvard University)H-Index: 13
#2Szu-Ta ChenH-Index: 1
Last. Sonia Hernandez-DiazH-Index: 82
view all 10 authors...
BACKGROUND Identifying pregestational diabetes in pregnant women using administrative claims databases is important for studies of the safety of antidiabetic treatment in pregnancy, but limited data are available on the validity of case-identifying algorithms. The purpose of this study was to evaluate the validity of an administrative claims-based algorithm to identify pregestational diabetes. METHODS Using a cohort of pregnant women nested within the Medicaid Analytic Extract (MAX) database, we...
Source
#1Daina B. Esposito (BU: Boston University)H-Index: 10
#2Brian T. Bateman (Brigham and Women's Hospital)H-Index: 65
Last. Krista F. Huybrechts (Brigham and Women's Hospital)H-Index: 53
view all 7 authors...
Opioids affect placental development and function in animal models, but human data on their association with ischemic placental disease are limited. Using a cohort of pregnant women in the US nationwide Medicaid Analytic eXtract (2000-2014), we compared women with ≥2 opioid dispensings in pregnancy to unexposed women. Given an uncertain etiologically relevant window, we assessed exposure occurring in early pregnancy, late and not early pregnancy, and both early and late pregnancy. For placental ...
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#1Krista F. Huybrechts (Harvard University)H-Index: 53
#2Martin Kulldorff (Brigham and Women's Hospital)H-Index: 76
Last. Shirley V. Wang (Brigham and Women's Hospital)H-Index: 21
view all 7 authors...
We rely on post-marketing approaches to define the risk of medications in pregnancy because information at the time of drug approval is limited. Most studies in pregnancy focus on a single or selected outcomes. However, women must balance the benefit of treatment against all possible adverse effects. Our objective was to apply and evaluate a tree-based scan statistic data mining method (TreeScan) as a safety surveillance approach that allows for simultaneous evaluation of a comprehensive range o...
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