Luisa A. Helguero
University of Aveiro
CancerEndocrinologyCellular differentiationGene expressionReceptorEstrogen receptor alphaChemistryEstrogenMammary glandStem cellCancer researchBreast cancerCancer stem cellCarcinogenesisCell growthMedicineEstrogen receptorBiologyCell biologyProgesterone receptor
Publications 62
#1Abdelkader NaouriH-Index: 1
#2Amar DjemouiH-Index: 1
Last. Artur M. S. Silva (University of Aveiro)H-Index: 45
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Abstract A new series of diverse 1,2,3-triazole-acridinedione/xanthenedione and 1,2-isoxazole-acridinedione/xanthenedione heterocyclic hybrids have been synthesized via 1,3-dipolar coupling reaction of N/O-substituted-acridinedione-alkyne or O-substituted-xanthenedione-alkyne substrates with various aromatic azides or oximes. In all cases, the cycloaddition is totally regioselective. The chemical structures of the synthesized compounds are determined using 2D NMR and are further confirmed by sin...
3 CitationsSource
#1Daniela BispoH-Index: 1
#2Victoria T. FabrisH-Index: 9
Last. Ana M. GilH-Index: 43
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#1Diana LopesH-Index: 7
#2Tânia MeloH-Index: 15
Last. Maria Rosário DominguesH-Index: 27
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4 CitationsSource
#1Carina Bernardo (University of Aveiro)H-Index: 5
#2Júlio Santos (University of Porto)H-Index: 6
Last. Lúcio Lara SantosH-Index: 28
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Abstract Estrogen-like metabolites have been identified in S. haematobium, the helminth parasite that causes urogenital schistosomiasis (UGS) and in patients´ blood and urine during UGS. Estrogen receptor (ER) activation is enriched in the luminal molecular subtype bladder cancer (BlaCa). To date, the significance of ER to these diseases remains elusive. We evaluated ERα and ERβ expression in UGS-related BlaCa (n = 27), UGS-related non-malignant lesions (n = 35), and noninfected BlaCa (n = 80). ...
1 CitationsSource
#1Deolinda Santinha (University of Aveiro)H-Index: 7
#2Anna Klopot (KI: Karolinska Institutet)H-Index: 1
Last. Luisa A. Helguero (University of Aveiro)H-Index: 26
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Abstract Liver X receptor (LXR) agonists have the potential to alleviate obesity related diseases, particularly atherosclerosis. However, LXRs are transcriptional regulators that induce de novo lipogenesis and lipid accumulation in hepatocytes which represents a serious adverse effect. In this work, we sought to characterize the LXR agonist GW3965 effects on fatty acid (FA) and phospholipid (PL) remodelling and the correlation with gene expression in order to better understand the underlying eff...
2 CitationsSource
#1Amar DjemouiH-Index: 1
#2Abdelkader NaouriH-Index: 1
Last. Artur M. S. Silva (University of Aveiro)H-Index: 45
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Abstract Novel series of triazole-benzimidazole-chalcone hybrid compounds have been synthesized via click chemistry, between different azide derivatives and substituted benzimidazole terminal alkynes bearing a chalcone moiety. The starting alkynes are prepared via base-catalysed nitrogen alkylation of pre-synthetized benzimidazole-chalcone substrates. All the intermediates as well as the final products are fully characterized by 1D and 2D NMR and mass spectrometry techniques. HMBC correlations p...
2 CitationsSource
#1Rita Araújo (University of Aveiro)H-Index: 17
#2Daniela Bispo (University of Aveiro)H-Index: 1
Last. Ana M. Gil (University of Aveiro)H-Index: 43
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Abstract Background Metabolomic strategies have been extensively used to search for biomarkers of disease, including cancer, in biological complex mixtures such as cells, tissues and biofluids. In breast cancer research, murine models are of great value and metabolomics has been increasingly applied to characterize tumor or organ tissues, or biofluids, for instance to follow-up metabolism during cancer progression or response to specific therapies. Scope of review This review briefly introduces ...
1 CitationsSource
#2Inês Direito (University of Aveiro)H-Index: 3
Last. Luisa A. HelgueroH-Index: 26
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