Mani Prabaharan
Hindustan University
Self-healing hydrogelsMicelleDrug carrierBiomedical engineeringNuclear chemistryControlled releaseNanotechnologyOrganic chemistryChemistryPolymer chemistryMaterials scienceGuar gumBiocompatibilityEthylene glycolBiomaterialSwellingChitosanDrug deliveryMTT assayChitinChemical engineeringTissue engineeringPolymerAmphiphile
67Publications
34H-index
6,427Citations
Publications 62
Newest
#1A.S. SoubhagyaH-Index: 1
#2K. BalagangadharanH-Index: 11
Last. Mani PrabaharanH-Index: 34
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Three-dimensional (3D) porous films based on chitosan (CS)/carboxymethyl guar gum (CMGG) polyelectrolyte complex (PEC) containing titanium dioxide nanoparticles (TiO2 NPs) were prepared as a wound-healing material by the freeze-drying process. The physicochemical properties of these films were evaluated by FTIR, XRD, SEM and EDX analysis. Furthermore, the swelling degree, porosity, in vitro biodegradation and compression strength of these films were examined. The developed films showed the bioco...
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#1P.R. Sivashankari (Hindustan University)H-Index: 4
Last. Mani PrabaharanH-Index: 34
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#1A.S. Soubhagya (Hindustan University)H-Index: 1
#2A. MoorthiH-Index: 1
Last. Mani Prabaharan (Hindustan University)H-Index: 34
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Three-dimensional (3D) porous films based on chitosan/pectin/ZnO nanoparticles (NPs) were prepared for wound healing by the freeze-drying method. The chemical nature, composition and morphology of these films were revealed by FTIR, XRD, EDX, SEM and BET analysis. SEM micrographs showed a decrease in the pore size and porosity of chitosan/pectin/ZnO films when increasing the content of ZnO NPs. The developed films presented the swelling degree and water retention ability in the range of 189-465 a...
13 CitationsSource
#1P.R. Sivashankari (Hindustan University)H-Index: 4
#2Mani Prabaharan (Hindustan University)H-Index: 34
Abstract Three-dimensional (3D) porous scaffolds based on agarose/chitosan/graphene oxide (ACGO) composite were prepared by the freeze-drying technique. The prepared scaffolds were characterized by FTIR, XRD and SEM analysis. The effect of graphene oxide (GO) on the physicochemical and biological properties of the composite scaffolds was evaluated in terms of porosity, swelling, water retention, compressive strength, enzymatic degradation, cytotoxicity and cell attachment behaviors. The ACGO com...
19 CitationsSource
#1Shalini Rajkumar (Hindustan University)H-Index: 14
#2Mani Prabaharan (Hindustan University)H-Index: 34
Last. M Prabaharan (Hindustan University)H-Index: 4
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ABSTRACT A novel type of multi-functional fluorescein isothiocyanate (FITC)-silica (SiO2)@gold (Au) core-shell nanoparticles covered with folic acid (FA)-conjugated guar gum succinate (GGS) and doxorubicin (DOX) (FITC-SiO2@Au-DOX-GGS-FA NPs) was prepared for imaging and therapy of cancer. The physicochemical properties of these NPs were analyzed with 1H NMR, TEM and DLS. The FITC-SiO2@Au-DOX-GGS-FA NPs exhibited the fluorescence and X-ray attenuation properties due to the presence of FITC-SiO2@A...
8 CitationsSource
#1D. Sathya SeeliH-Index: 3
Last. Mani PrabaharanH-Index: 34
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#1Shalini Rajkumar (Hindustan University)H-Index: 14
#2Mani Prabaharan (Hindustan University)H-Index: 34
Last. M Prabaharan (Hindustan University)H-Index: 4
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Abstract Multi-functional core-shell Fe3O4@Au nanoparticles (Fe3O4@Au-DOX-mPEG/PEG-FA NPs) conjugated with doxorubicin (DOX), methoxy poly(ethylene glycol) (mPEG), and folic acid-linked poly(ethylene glycol) (PEG-FA) were synthesized for cancer theranostic applications. In the developed NPs, the DOX was chemically conjugated at the surface of core-shell Fe3O4@Au NPs using L-cysteine methyl ester (LCME) as a linker by acid-sensitive hydrazone bond. The formation of Fe3O4@Au-DOX-mPEG/PEG-FA NPs wa...
27 CitationsSource
#1Shalini Rajkumar (Hindustan University)H-Index: 14
#1S. Rajkumar (Hindustan University)H-Index: 1
Last. M. Prabaharan (Hindustan University)H-Index: 1
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Abstract Recent developments in nanoscience and technology have enabled the design and construction of multifunctional nanoparticles (NPs), which combine targeting, therapeutic, and diagnostic functions within a single nanoscale structure. The theranostic abilities of iron oxide–gold (Fe3O4–Au) hybrid NPs have received tremendous attention over the past decade as a promising tool for cancer treatment and diagnosis. Fe3O4–Au hybrid NPs shows a great prospective in the area of biomedical sciences ...
5 CitationsSource
#1P.R. Sivashankari (Hindustan University)H-Index: 4
#1P.R. Sivashankari (Hindustan University)H-Index: 1
Last. Mani Prabaharan (Hindustan University)H-Index: 34
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Abstract Chitosan, a cationic pseudonatural biopolymer obtained from the partial deacetylation of chitin, has gained much importance in the biomedical field over past few years. It has primary amine groups that impart many unique characteristics such as antimicrobial activity, hemostatic activity, biocompatibility, and biodegradability. Moreover, the structure of chitosan mimics the extracellular matrix (ECM) environment, as it is made up of N -acetyl d -glucosamine and d -glucosamine residues. ...
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#1Shalini Rajkumar (Hindustan University)H-Index: 14
#2Mani Prabaharan (Hindustan University)H-Index: 34
Last. M Prabaharan (Hindustan University)H-Index: 4
view all 2 authors...
Abstract Multi-functional nanocarriers based on iron oxide nanoparticles (IONPs) conjugated with doxorubicin (DOX), poly(ethylene glycol) (PEG), and folic acid (FA) (IO-MMA-DOX-PEG-OCH3/FA) were prepared as theranostics for cancer therapy. Using mono-methyl adipate (MMA) as a linker, the anticancer drug, DOX, was conjugated on the surface of IONPs by acid-cleavable hydrazone bond. The average size of the IO-MMA-DOX-PEG-OCH3/FA nanocarriers was determined as 14 and 40 nm by TEM and DLS, respectiv...
12 CitationsSource