Traci M. Bartz
University of Washington
GeneGenome-wide association studyInternal medicineEndocrinologySingle-nucleotide polymorphismCardiologyGenetic associationProspective cohort studyHazard ratioHeart failureDiseaseAtrial fibrillationPopulationCardiovascular healthProportional hazards modelStrokeGeneticsMedicineCohortBiologyMeta-analysis
Publications 169
#1Daniele MasseraH-Index: 9
#2Mo Hu (NU: Northwestern University)H-Index: 1
Last. Jorge R. Kizer (UCSF: University of California, San Francisco)H-Index: 60
view all 11 authors...
Objectives null Speckle-tracking echocardiography enables detection of abnormalities in cardiac mechanics with higher sensitivity than conventional measures of left ventricular (LV) dysfunction and may provide insight into the pathogenesis of coronary heart disease (CHD). We investigated the relationship of LV longitudinal strain, LV early diastolic strain rate (SR) and left atrial (LA) reservoir strain with long-term CHD incidence in community-dwelling older adults. null Methods null The associ...
#1Min-A Jhun (UM: University of Michigan)
#1Mina-A Jhun (UM: University of Michigan)
Last. Åsa K. Hedman (Science for Life Laboratory)H-Index: 29
view all 64 authors...
#1Santosh B. Murthy (Cornell University)H-Index: 19
#2Cenai Zhang (Cornell University)H-Index: 3
Last. Hooman Kamel (Cornell University)H-Index: 57
view all 18 authors...
Importance Intracerebral hemorrhage and arterial ischemic disease share risk factors, to our knowledge, but the association between the 2 conditions remains unknown. Objective To evaluate whether intracerebral hemorrhage was associated with an increased risk of incident ischemic stroke and myocardial infarction. Design, Setting, and Participants An analysis was conducted of pooled longitudinal participant-level data from 4 population-based cohort studies in the United States: the Atherosclerosis...
1 CitationsSource
#1Mina-A Jhun (UM: University of Michigan)
#2Michael M. Mendelson (Boston Children's Hospital)H-Index: 22
Last. Åsa K. Hedman (Science for Life Laboratory)H-Index: 29
view all 64 authors...
Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglyc...
#1Monali Shah (RU: Rutgers University)
#2Carlos J. Rodriguez (Albert Einstein College of Medicine)H-Index: 4
Last. John S. Gottdiener (UMB: University of Maryland, Baltimore)H-Index: 106
view all 8 authors...
Heart failure (HF) and myocardial infarction are serious complications of major noncardiac surgery in older adults. Many factors can contribute to the development of HF during the postoperative period. The incidence of, and risk factors for, procedure-associated heart failure (PHF) occurring at the time of, or shortly after, medical procedures in a population-based sample ≥ 65 years of age have not been fully characterized, particularly in comparison with HF not proximate to medical procedures. ...
#1Danielle E. Haslam (Harvard University)H-Index: 6
#2Gina M. Peloso (BU: Boston University)H-Index: 58
Last. Niina Pitkänen (UTU: University of Turku)H-Index: 15
view all 56 authors...
Background - Carbohydrate responsive element binding protein (ChREBP) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations. We hypothesized SSB consumption would modify the association between genetic variants in the CHREBP locus and dyslipidemia. Methods - Data from 11 cohorts from the Cohort...
#1Eliana Portilla-Fernandez (Erasmus University Medical Center)H-Index: 8
#2Shih-Jen Hwang (NIH: National Institutes of Health)H-Index: 81
Last. Symen Ligthart (Erasmus University Medical Center)H-Index: 27
view all 45 authors...
Common carotid intima-media thickness (cIMT) is an index of subclinical atherosclerosis that is associated with ischemic stroke and coronary artery disease (CAD). We undertook a cross-sectional epigenome-wide association study (EWAS) of measures of cIMT in 6400 individuals. Mendelian randomization analysis was applied to investigate the potential causal role of DNA methylation in the link between atherosclerotic cardiovascular risk factors and cIMT or clinical cardiovascular disease. The CpG sit...
#1David S. Owens (UW: University of Washington)H-Index: 25
#2Traci M. Bartz (UW: University of Washington)H-Index: 40
Last. Jorge R. KizerH-Index: 60
view all 10 authors...
OBJECTIVES Current estimates of aortic stenosis (AS) frequency have mostly relied on cross-sectional echocardiographic or longitudinal administrative data, making understanding of AS burden incomplete. We performed case adjudications to evaluate the frequency of AS and assess differences by age, sex and race in an older cohort with long-term follow-up. METHODS We developed case-capture methods using study echocardiograms, procedure and diagnosis codes, heart failure events and deaths for targete...
1 CitationsSource
#1Alexander E. Merkler (Cornell University)H-Index: 20
#2Traci M. Bartz (UW: University of Washington)H-Index: 40
Last. W. T. Longstreth (UW: University of Washington)H-Index: 100
view all 10 authors...
Objective: To test the hypothesis that silent MI is a risk factor for ischemic stroke, we evaluated the association between silent MI and subsequent ischemic stroke in the Cardiovascular Health Study. Methods: The Cardiovascular Health Study prospectively enrolled community-dwelling individuals ≥65 years of age. We included participants without prevalent stroke or baseline evidence of MI. Our exposures were silent and clinically apparent, overt MI. Silent MI was defined as new evidence of Q-wave...
1 CitationsSource
#1Matthew Moll (Brigham and Women's Hospital)H-Index: 8
#2Victoria E. Jackson (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 15
Last. Brian D. Hobbs (Brigham and Women's Hospital)H-Index: 18
view all 33 authors...
Genome-wide association studies (GWASs) have identified regions associated with chronic obstructive pulmonary disease (COPD). GWASs of other diseases have shown an approximately 10-fold overrepresentation of nonsynonymous variants, despite limited exonic coverage on genotyping arrays. We hypothesized that a large-scale analysis of coding variants could discover novel genetic associations with COPD, including rare variants with large effect sizes. We performed a meta-analysis of exome arrays from...