Alya Annabi
Tunis University
Internal medicineEndocrinologyChemistryImmunologySuperoxide dismutaseOxidative stressMalathionType 2 diabetesCarbosulfanInsulin resistanceAcetylcysteineAntioxidantInsulinToxicityGlucose homeostasisCholinesteraseGlutathioneBiochemistryDiabetes mellitusBiologyPharmacology
19Publications
14H-index
511Citations
Publications 19
Newest
#1Ines Bini Dhouib (Tunis University)H-Index: 9
#2Alya Annabi (Tunis University)H-Index: 14
Last. Asma Gati (Tunis University)H-Index: 3
view all 11 authors...
Curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. This study aimed to investigate the effect of curcumin on neurobehavioral and neuropathological alterations induced by acetamiprid on male rats. Three groups of ten male Wistar rats each were used for the study: the first was a control group (CTR) that did not consume ac...
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#1Ines El-Bini Dhouib ('ENS Paris': École Normale Supérieure)H-Index: 3
#2Manel Jallouli (Tunis University)H-Index: 7
Last. Mohamed Montassar Lasram (Tunis University)H-Index: 14
view all 6 authors...
N-acetylcysteine (NAC), a cysteine pro-drug and glutathione precursor has been used in therapeutic practices for several decades, as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication. There is a growing interest concerning the beneficial effects of NAC against the early stages of toxicity-induced by pesticides. Nevertheless, the mechanisms underlying the therapeutic and clinical applications of NAC are not fully understood. In this review we aimed t...
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#1Ines Bini Dhouib (University of the Sciences)H-Index: 1
#2Alya AnnabiH-Index: 14
Last. Mohamed Montassar LasramH-Index: 14
view all 7 authors...
In the literature, carbamates pesticides (CMs) have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulatory factors and modifying immune tolerance. In the present study, oxidative stress and inhibition of est...
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#1Ines Bini Dhouib (Tunis University)H-Index: 9
#2Manel Jallouli (Tunis University)H-Index: 7
Last. Mohamed Montassar Lasram (Tunis University)H-Index: 14
view all 7 authors...
The immune system can be the target of many chemicals, with potentially severe adverse effects on the host’s health. In the literature, carbamate (CM) pesticides have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate, or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for i...
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Imidacloprid (IMI) is known to target the nicotinic acetylcholine receptors (nAChRs) in insects, and potentially in mammals. However, IMI toxicity on mammalian tissues has not been adequately evaluated. The aim of the present study was to examine whether IMI induced functional impairment in hypthalamic-pituitary-adrenal (HPA) axis tissues. An oral exposure of 40 mg IMI/kg for 28 days in male rats caused a significant increase in malondialdehyde (MDA) level. The antioxidant catalase, superoxide d...
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#2Ines Bini DhouibH-Index: 9
Last. Najoua GharbiH-Index: 24
view all 5 authors...
Abstract Objective N-acetylcysteine (NAC), a cysteine pro-drug and glutathione precursor has been used in therapeutic practices for several decades, as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication. There is a growing interest concerning the beneficial effects of NAC against the early stages of type-2 diabetes development. Nevertheless, the mechanisms underlying the therapeutic and clinical applications of NAC are not fully understood. In this r...
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Abstract Organophosphorus (OP) and carbamate (CM) pesticides are widely used in agriculture. These pesticides are highly toxic to humans and their residues in food pose potential threat to human health. In this comparative study, we investigated the effect of subchronic exposure of OPs (malathion, MAL) and CM (Carbosulfan, CB) on rat liver and spleen. Biochemical analysis showed that levels of hepatic enzymes (ALT, ALP, LDH and PAL) changed after exposure to the pesticides. In the liver extracts...
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#1Mohamed Montassar Lasram (Tunis University)H-Index: 14
#2Kahena BouzidH-Index: 8
Last. Najoua Gharbi (Tunis University)H-Index: 24
view all 8 authors...
AbstractSeveral studies showed that organophosphorus pesticides disturb glucose homeostasis and can increase incidence of metabolic disorders and diabetes via insulin resistance. The current study investigates the influence of malathion on glucose metabolism regulation, in vivo, during subchronic exposure. Malathion was administered orally (200 mg/kg), once a day for 28 consecutive days. Plasma glucose, insulin and Glycated hemoglobin levels were significantly increased while hepatic glycogen co...
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AbstractImidacloprid is the most important example of the neonicotinoid insecticides known to target the nicotinic acetylcholine receptor in insects, and potentially in mammals. N-Acetyl-l-cysteine (NAC) has been shown to possess curative effects in experimental and clinical investigations. The present study was designed to evaluate the recovery effect of NAC against Imidacloprid-induced oxidative stress and cholinergic transmission alteration in hypothalamic–pituitary–adrenal (HPA) axis of male...
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Abstract Organophosphorus pesticides are known to disturb glucose homeostasis and increase incidence of metabolic disorders and diabetes via insulin resistance. The current study investigates the influence of malathion on insulin signaling pathways and the protective effects of N-acetylcysteine (NAC). Malathion (200 mg/kg) and NAC (2 g/l) were administered orally to rats, during 28 consecutive days. Malathion increases plasma glucose, plasma insulin and glycated hemoglobin levels. Further, we ob...
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