Laura R. Sadofsky
Hull York Medical School
Internal medicineMolecular biologyTransient receptor potential channelTRPV1ReceptorHEK 293 cellsCalcium in biologyAnkyrinChemistryImmunologyStimulationInflammationCytokinePopulationFlow cytometryMedicineCell cultureBiologyCell biologyPharmacology
39Publications
12H-index
887Citations
Publications 39
Newest
Abstract null null Knowledge regarding the presence of suspended microplastics (MPs) within the air is lacking, especially indoors, yet the importance of indoor air quality and human health is rising. This study is the first to report MPs within multiple homes over a 6-month period, with concentrations exceeding previous outdoor studies. Twenty households, within the City of Hull and Humber region, U.K., were passively sampled, each month, collecting atmospheric fallout at head height for subseq...
1 CitationsSource
#1Samantha K. Atkinson (Hull York Medical School)H-Index: 2
#2Alyn H. Morice (Hull York Medical School)H-Index: 2
Last. Laura R. Sadofsky (Hull York Medical School)H-Index: 12
view all 3 authors...
Human rhinovirus (RV) is the most common cause of upper respiratory tract infection (URTI) and chronic airway disease exacerbation. Cough is present in 50–80% of URTI cases, accompanied by heightened airway hypersensitivity, yet no effective treatment currently exists for this infectious cough. The mechanism by which RV causes cough and airway hypersensitivity in URTI is still unknown despite recent advances in potential therapies for chronic cough. The effect of RV-16 infection (MOI 1) on intra...
2 CitationsSource
#1Laura R. Sadofsky (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 2
view all 9 authors...
Purpose There is currently no true macrophage cell line and in vitro experiments requiring these cells currently require mitogenic stimulation of a macrophage precursor cell line (THP-1) or ex vivo maturation of circulating primary monocytes. In this study, we characterise a human macrophage cell line, derived from THP-1 cells, and compare its phenotype to the THP-1 cells.
1 CitationsSource
#1Arundhasa Chandrabalan (Hull York Medical School)H-Index: 1
#2Martin J. McPhillie (University of Leeds)H-Index: 7
Last. Laura R. Sadofsky (Hull York Medical School)H-Index: 12
view all 5 authors...
The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators has not been fully elucidated. N-cinnamoylanthranilic acid derivatives (CADs) contain structural elements from the TRPA1 modulators cinnamaldehyde and flufenamic acid, so it was hypothesized that specific modulators could be found amongst them and m...
7 CitationsSource
#1Jesse Vance (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 2
#2Andres Santos (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 5
Last. Jorge Cervantes (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 8
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Purpose Diabetes mellitus (DBM) reduces immunological activity and increases susceptibility to various infections, including tuberculosis (TB). Human alveolar macrophage (hAM) functions are altered in DBM.
9 CitationsSource
#1Robert T Bennett (Hull York Medical School)H-Index: 3
#2ME Cowen (Hull York Medical School)
Last. Alyn H. Morice (Hull York Medical School)H-Index: 35
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Introduction and objectives Oxygen is often used inappropriately in hospital for patients without significant systemic hypoxia. In lung disease correcting hypoxia has become a key treatment target. Here for the first time we explore the effect of oxygen on airway tone in human lung models. Methods Human lung specimens were obtained at resection for cancer. Rings of human bronchi were mounted in 25 ml organ baths for continuous recording of isometric tension. The effect of changing the oxygen ten...
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#1RJ Stinson (Hull York Medical School)
#2Alyn H. Morice (Hull York Medical School)H-Index: 35
Last. Laura R. Sadofsky (Hull York Medical School)H-Index: 12
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Introduction and objective URTI and chronic cough is estimated to cost the UK economy in excess of £1 billion annual however, the mechanism of cough hypersensitivity remains elusive. Neuromodulation provides a promising hypothesis whereby the purinoreceptor P2 × 3 on vagal afferent nerve fibres is activated through the release of extracellular ATP. Stimulation of the polymodal transient receptor potential channels (TRPV4) may trigger release of ATP. This experimental method aims to detect calciu...
Source
#1Samantha K. Atkinson (Hull York Medical School)H-Index: 2
#2Alyn H. MoriceH-Index: 35
Last. Laura R. SadofskyH-Index: 12
view all 3 authors...
Rational and hypothesis: Human rhinovirus (HRV) infections are a major causative agent of upper respiratory tract infection (URTI) and are associated with acute exacerbations of asthma and COPD. URTI is associated with excessive production of mucus within the airway, particularly in sufferers of chronic respiratory conditions. This mucus may lead to altered osmolality within the airway and contribute to hypotonic stimulus of the airway epithelium and airway hypersensitivity leading to cough. Hyp...
Source
#1Laura R. Sadofsky (Hull York Medical School)H-Index: 12
#2Yvette A. Hayman (Hull York Medical School)H-Index: 3
Last. Alyn H. Morice (Hull York Medical School)H-Index: 2
view all 4 authors...
1 CitationsSource
#1Eric Vancauwenberghe (university of lille)H-Index: 2
#2Lucile Noyer (university of lille)H-Index: 5
Last. Morad Roudbaraki (university of lille)H-Index: 29
view all 18 authors...
Previous studies showed the effects of resveratrol (RES) on several cancer cells, including prostate cancer (PCa) cell apoptosis without taking into consideration the impact of the tumor microenvironment (TME). The TME is composed of cancer cells, endothelial cells, blood cells, and cancer-associated fibroblasts (CAF), the main source of growth factors. The latter cells might modify in the TME the impact of RES on tumor cells via secreted factors. Recent data clearly show the impact of CAF on ca...
17 CitationsSource