T. Alp Ikizler
United States Department of Veterans Affairs
Internal medicineEndocrinologySurgeryRenal functionIntensive care medicineProspective cohort studyCohort studyHemodialysisKidney diseaseDiseaseWastingDialysisCreatinineAcute kidney injuryPopulationNephrologyDiabetes mellitusMedicineCohortGastroenterology
Publications 335
#1T. Alp Ikizler (VUMC: Vanderbilt University Medical Center)H-Index: 90
One of the most encountered complications of ESKD, especially for patients undergoing maintenance hemodialysis, is the subtle but clinically important progressive deterioration of nutritional status. This unique state of metabolic and nutritional derangements, termed protein-energy wasting (PEW), is
#1Ian E. McCoy (UCSF: University of California, San Francisco)
#2Sandeep Brar (UBC: University of British Columbia)
Last. T. Alp Ikizler (VUMC: Vanderbilt University Medical Center)H-Index: 90
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Background null There has recently been considerable interest in better understanding how blood pressure should be managed after an episode of hospitalized AKI, but there are scant data regarding the associations between blood pressure measured after AKI and subsequent adverse outcomes. We hypothesized that among AKI survivors, higher blood pressure measured three months after hospital discharge would be associated with worse outcomes. We also hypothesized these associations between blood pressu...
#1Anup P. Challa (VUMC: Vanderbilt University Medical Center)H-Index: 2
#2Nicole M. Zaleski (VUMC: Vanderbilt University Medical Center)H-Index: 3
Last. Raymond C. Harris (VUMC: Vanderbilt University Medical Center)H-Index: 91
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Repurposing is an increasingly attractive method within the field of drug development for its efficiency at identifying new therapeutic opportunities among approved drugs at greatly reduced cost and time of more traditional methods. Repurposing has generated significant interest in the realm of rare disease treatment as an innovative strategy for finding ways to manage these complex conditions. The selection of which agents should be tested in which conditions is currently informed by both human...
#1T. Alp Ikizler (VUMC: Vanderbilt University Medical Center)H-Index: 90
#2Jonathan Himmelfarb (UW: University of Washington)H-Index: 90
#1Usman J. Wudil (VUMC: Vanderbilt University Medical Center)H-Index: 2
#2Muktar H. Aliyu (VUMC: Vanderbilt University Medical Center)H-Index: 33
Last. C. William Wester (VUMC: Vanderbilt University Medical Center)H-Index: 24
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Abstract HIV-positive adults are at risk for various kidney diseases, and apolipoprotein 1 (APOL1) high-risk genotypes increase this risk. This study aimed to determine the prevalence and ethnic distribution of APOL1 risk genotypes among a cohort of HIV-positive Nigerian adults and explore the relationship between APOL1 risk variant status with albuminuria and estimated glomerular filtration rate (eGFR). We conducted a cross-sectional study among 2 458 persons living with HIV who attended an HIV...
1 CitationsSource
#1Melis Sahinoz (VA: United States Department of Veterans Affairs)H-Index: 1
#1Melis Sahinoz (VUMC: Vanderbilt University Medical Center)
Last. T. Alp Ikizler (Vandy: Vanderbilt University)H-Index: 90
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BACKGROUND Tissue sodium content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) were previously explored using 23Sodium magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of sodium stores in patients on dialysis as well as the factors influencing this sodium accumulation. METHODS In this cross-sectional study, we quantified the calf muscle and skin sodium content in 162 subjects (10 PD, 33 MHD patients, and 119 controls) using 23...
2 CitationsSource
#1Elvis A. Akwo (Vandy: Vanderbilt University)H-Index: 8
#2Cassianne Robinson-Cohen (Vandy: Vanderbilt University)H-Index: 34
Last. Edward D. Siew (Vandy: Vanderbilt University)H-Index: 37
view all 24 authors...
Apparent treatment-resistant hypertension (ATRH) has been linked to end-stage kidney disease (ESKD) and cardiovascular disease. We tested the hypothesis that the effect of ATRH on ESKD is greater i...
#1T. Alp Ikizler (VUMC: Vanderbilt University Medical Center)H-Index: 90
#2P. Toby Coates (University of Adelaide)H-Index: 27
Last. Pierre Ronco (French Institute of Health and Medical Research)H-Index: 79
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Abstract In this issue of the Journal, the initial experience regarding the immunogenicity of prior COVID-19 infection and the response to the COVID-19 vaccines among patients on maintenance dialysis and kidney transplant recipients is summarized. Preliminary data suggest that there is reasonable durability of immune response after COVID19 infection. While immune response to first dose of vaccine is less than acceptable in both groups, a significant portion of maintenance dialysis patients devel...
7 CitationsSource
#1Helen L. MacLaughlin (QUT: Queensland University of Technology)H-Index: 15
#2Mindy Pike (VUMC: Vanderbilt University Medical Center)H-Index: 4
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BACKGROUND Acute kidney injury (AKI) and obesity are independent risk factors for chronic kidney disease (CKD). This study aimed to determine if obesity modifies risk for CKD outcomes after AKI. METHODS This prospective multisite cohort study followed adult survivors after hospitalization, with or without AKI. The primary outcome was a combined CKD event of incident CKD, progression of CKD and kidney failure, examined using time-to-event Cox proportional hazards models, adjusted for diabetes sta...
#1Edward D. Siew (VUMC: Vanderbilt University Medical Center)H-Index: 37
#2Sharidan K. Parr (VUMC: Vanderbilt University Medical Center)H-Index: 11
Last. Michael E. MathenyH-Index: 47
view all 12 authors...
Recurrent episodes of acute kidney injury (AKI) are common among AKI survivors. Renin-angiotensin aldosterone inhibitors (RAASi) are often indicated for these patients but may increase the risk for recurrent AKI. Here, we examined whether RAASi associates with a higher risk for recurrent AKI and mortality among survivors of moderate to severe AKI in a retrospective cohort of Veterans who survived Stage II or III AKI. The primary exposure was RAASi at hospital discharge and the primary endpoint w...
5 CitationsSource