Pirjo Nuutila
University of Turku
Internal medicineEndocrinologyPerfusionBlood flowCardiologyAdipose tissueChemistryPositron emission tomographyType 2 diabetesInsulin resistanceGlucose uptakeInsulinSkeletal muscleBrown adipose tissueHyperinsulinemiaNuclear medicineObesityWeight lossDiabetes mellitusMedicineBiology
Publications 443
#1Tuulia Malén (UTU: University of Turku)H-Index: 1
#2Tomi Karjalainen (UTU: University of Turku)H-Index: 8
Last. Juha O. Rinne (UTU: University of Turku)H-Index: 102
view all 11 authors...
BACKGROUND: The dopamine system contributes to a multitude of functions ranging from reward and motivation to learning and movement control, making it a key component in goal-directed behavior. Altered dopaminergic function is observed in neurological and psychiatric conditions. Numerous factors have been proposed to influence dopamine function, but due to small sample sizes and heterogeneous data analysis methods in previous studies their specific and joint contributions remain unresolved. METH...
#1Elina PeltolaH-Index: 1
#2Päivi M. HannulaH-Index: 4
Last. Pirjo Nuutila (TYKS: Turku University Hospital)H-Index: 87
view all 16 authors...
OBJECTIVE Insulinomas are rare functional pancreatic neuroendocrine tumours. As previous data on the long-term prognosis of insulinoma patients are scarce, we studied the morbidity and mortality in the Finnish insulinoma cohort. DESIGN Retrospective cohort study Methods: Incidence of endocrine, cardiovascular, gastrointestinal and psychiatric disorders, and cancers was compared in all the patients diagnosed with an insulinoma in Finland during 1980-2010 (n=79, including two patients with multipl...
#1Marti Boss (Radboud University Nijmegen)H-Index: 5
#2Christof Rottenburger (University Hospital of Basel)H-Index: 8
Last. Pirjo Nuutila (UTU: University of Turku)H-Index: 87
view all 17 authors...
Surgery with curative intent can be offered to Congenital Hyperinsulinism (CHI) patients, provided that the lesion is focal. Radiolabeled Exendin-4 specifically binds the glucagon-like peptide 1 receptor (GLP-1R) on pancreatic beta cells. In this study we compared the performance of [18F]F-DOPA positron emission tomography/computed tomography (DOPA PET) and PET/CT with the new tracer [68Ga]Ga-NODAGA-exendin-4 (Exendin PET) in the preoperative detection of focal CHI. Methods: Nineteen CHI patient...
#1Jonas Oldgren (Uppsala University)H-Index: 51
#2Sanna M. Laurila (TYKS: Turku University Hospital)H-Index: 1
Last. Pirjo Nuutila (TYKS: Turku University Hospital)H-Index: 87
view all 16 authors...
Aims To explore early effects of dapagliflozin on myocardial function and metabolism in patients with type 2 diabetes without heart failure. Materials and methods Patients with type 2 diabetes on metformin treatment were randomized to double-blind 6-week placebo or dapagliflozin 10 mg daily treatment. Investigations included cardiac function and structure with myocardial resonance imaging (MRI); cardiac oxygen consumption, perfusion and efficiency with [11 C]-acetate positron emission tomography...
1 CitationsSource
#1Kirsi A. Virtanen (TYKS: Turku University Hospital)H-Index: 39
#2Pirjo Nuutila (UTU: University of Turku)H-Index: 87
A new study investigates brown adipose tissue (BAT) volume in young, metabolically healthy adults. The focus is on the associations between BAT volume and BMI, waist circumference, whole-body adipose tissue mass, visceral adipose tissue mass and cold-induced BAT activity. Of note, the reported associations differed in men and women.
#1Sanna Laurila (UTU: University of Turku)H-Index: 1
#2Lihua Sun (UTU: University of Turku)H-Index: 6
Last. Katja Steiger (TUM: Technische Universität München)H-Index: 32
view all 21 authors...
Brown adipose tissue (BAT) thermogenesis is activated by feeding. Recently, we revealed a secretin-mediated gut–BAT–brain axis, which stimulates satiation in mice, but the purpose of meal-induced BAT activation in humans has been unclear. In this placebo-controlled, randomized crossover study, we investigated the effects of intravenous secretin on BAT metabolism (measured with [18F]FDG and [15O]H2O positron emission tomography) and appetite (measured with functional magnetic resonance imaging) i...
1 CitationsSource
#1Henry K. Karlsson (TYKS: Turku University Hospital)H-Index: 13
#2Lauri Tuominen (U of O: University of Ottawa)H-Index: 2
Last. Lauri Nummenmaa (TYKS: Turku University Hospital)H-Index: 58
view all 6 authors...
Bariatric surgery is the most effective method for weight loss in morbid obesity. There is significant individual variability in the weight loss outcomes, yet factors leading to postoperative weight loss or weight regain remain elusive. Alterations in the µ-opioid receptor (MOR) and dopamine D2 receptor (D2R) systems are associated with obesity and appetite control, and the magnitude of initial brain receptor system perturbation may predict long-term surgical weight loss outcomes. We tested this...
#1Lauri Nummenmaa (UTU: University of Turku)H-Index: 58
Last. Vesa PutkinenH-Index: 13
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The endogenous mu-opioid receptor (MOR) system modulates a multitude of social and reward-related functions, and exogenous opiates also influence sex drive in humans and animals. However, there is no in vivo evidence for the contribution of MOR system on human sex drive. Here we measured healthy male subjects (n=52) brains MOR availability with positron emission tomography (PET) using an agonist radioligand, [11C]carfentanil, that has high affinity for MORs. Sex drive was measured using self-rep...
#1Mia Ståhle (UTU: University of Turku)H-Index: 7
#2Sanna Hellberg (UTU: University of Turku)H-Index: 11
Last. Anne Roivainen (UTU: University of Turku)H-Index: 37
view all 13 authors...
Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflammation. However, the expression of GLP-1R in atherosclerotic arteries remains uncertain. We evaluated whether a positron emission tomography (PET) tracer 68Ga-NODAGA-exendin-4 enables detection and imaging of GLP-1R expression in the mouse atherosclerotic aorta. Hypercholesterolemic (LDLR-/-ApoB100/100), hypercholesterolemic and diabetic (IGF-II/LDLR-/-ApoB100/100) as we...
#1Eleni RebelosH-Index: 11
#1Eleni Rebelos (TYKS: Turku University Hospital)H-Index: 1
Last. Laura L. EkbladH-Index: 6
view all 4 authors...
Imaging brain glucose metabolism with fluorine-labelled fluorodeoxyglucose ([18F]-FDG) positron emission tomography (PET) has long been utilized to aid the diagnosis of memory disorders, in particular in differentiating Alzheimer’s disease (AD) from other neurological conditions causing cognitive decline. The interest for studying brain glucose metabolism in the context of metabolic disorders has arisen more recently. Obesity and type 2 diabetes—two diseases characterized by systemic insulin res...