Felicita Pedata
University of Florence
Internal medicineEndocrinologyAdenosine A3 receptorNeuroscienceReceptorPurinergic signallingAdenosine A1 receptorChemistryStimulationAcetylcholineAdenosineAdenosine A2A receptorStriatumMicrodialysisIschemiaPurinergic receptorGlutamate receptorAdenosine receptorMedicineBiologyCell biologyPharmacology
178Publications
56H-index
5,767Citations
Publications 177
Newest
#1Elisabetta Coppi (UniFI: University of Florence)H-Index: 22
#2Federica Cherchi (UniFI: University of Florence)H-Index: 6
Last. Daniela Salvemini (SLU: Saint Louis University)H-Index: 80
view all 9 authors...
Agonists of the Gi protein-coupled A3 adenosine receptor (A3AR) have shown important pain-relieving properties in preclinical settings of several pain models. Active as a monotherapy against chronic pain, A3AR agonists can also be used in combination with classic opioid analgesics. Their safe pharmacological profile, as shown by clinical trials for other pathologies, i.e., rheumatoid arthritis, psoriasis and fatty liver diseases, confers a realistic translational potential, thus encouraging rese...
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#1Ilaria Dettori (UniFI: University of Florence)H-Index: 7
#2Irene Fusco (UniFI: University of Florence)H-Index: 5
Last. Felicita Pedata (UniFI: University of Florence)H-Index: 56
view all 13 authors...
Ischaemic stroke is a leading cause of death and disability. One of the major pathogenic mechanisms after ischaemia includes the switch to the glycolytic pathway, leading to tissue acidification. Carbonic anhydrase (CA) contributes to pH regulation. A new generation of CA inhibitors, AN11-740 and AN6-277 and the reference compound acetazolamide (ACTZ) were investigated in two models of brain ischaemia: in rat hippocampal acute slices exposed to severe oxygen, glucose deprivation (OGD) and in an ...
1 CitationsSource
#1Elisabetta Coppi (UniFI: University of Florence)H-Index: 22
#2Francesca Cencetti (UniFI: University of Florence)H-Index: 19
Last. Anna Maria Pugliese (UniFI: University of Florence)H-Index: 26
view all 8 authors...
Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain. Impairments in the process of myelination, or demyelinating insults, might cause chronic diseases such as multiple sclerosis (MS). Under physiological conditions, remyelination is an ongoing process throughout adult life consisting in the differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes (OLs). During pathological events, this process fails due to unfavourable environment. A...
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Ischemic stroke is a leading cause of death and disability worldwide. The only pharmacological treatment available to date for cerebral ischemia is tissue plasminogen activator (t-PA) and the search for successful therapeutic strategies still remains a major challenge. The loss of cerebral blood flow leads to reduced oxygen and glucose supply and a subsequent switch to the glycolytic pathway, which leads to tissue acidification. Carbonic anhydrase (CA, EC 4.2.1.1) is the enzyme responsible for c...
1 CitationsSource
#1Elisabetta CoppiH-Index: 22
#2Federica CherchiH-Index: 6
Last. Annamaria Morelli (UniFI: University of Florence)H-Index: 49
view all 11 authors...
The Nucleus Basalis of Meynert (NBM) is the main source of cholinergic neurons in the basal forebrain to be crucially involved in cognitive functions and whose degeneration correlates with cognitive decline in major degenerative pathologies as Alzheimer's and Parkinson's diseases. However, knowledge concerning NBM neurons derived from human brain is very limited to date. We recently characterized a primary culture of proliferating neuroblasts isolated from the human fetal NBM (hfNBM) as immature...
1 CitationsSource
#1Ilaria DettoriH-Index: 7
#2Lisa GavianoH-Index: 3
Last. Felicita PedataH-Index: 56
view all 9 authors...
Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to excitotoxicity, followed by a secondary brain injury that develops hours to days after ischemia. During ischemia, adenosine acts as an endogenous neuroprotectant agent. Few studies have investigated the role of A2B receptor in brain ischemia because of the low potency of adenosine for it and the few selective ligands developed so far. A2B receptors are scarcely but widely distributed in the brain on ne...
2 CitationsSource
#1Elisabetta CoppiH-Index: 22
#2Ilaria DettoriH-Index: 7
Last. Anna Maria PuglieseH-Index: 26
view all 7 authors...
2 CitationsSource
Adenosine is a signaling molecule, which, by activating its receptors, acts as an important player after cerebral ischemia. Here, we review data in the literature describing A2BR-mediated effects in models of cerebral ischemia obtained in vivo by the occlusion of the middle cerebral artery (MCAo) or in vitro by oxygen-glucose deprivation (OGD) in hippocampal slices. Adenosine plays an apparently contradictory role in this receptor subtype depending on whether it is activated on neuro-glial cells...
8 CitationsSource
#1Mauro Tettamanti (Mario Negri Institute for Pharmacological Research)H-Index: 37
#2Simone Beretta (University of Milan)H-Index: 23
Last. Antonio Vinciguerra (University of Naples Federico II)H-Index: 16
view all 27 authors...
Introduction Multicentre preclinical randomised controlled trials (pRCT) are emerging as a necessary step to confirm efficacy and improve translation into the clinic. The aim of this project is to perform two multicentre pRCTs (one in rats and one in mice) to investigate the efficacy of remote ischaemic conditioning (RIC) in an experimental model of severe ischaemic stroke. Methods and analysis Seven research laboratories within the Italian Stroke Organization (ISO) Basic Science network will pa...
1 CitationsSource
#1Elisabetta Coppi (UniFI: University of Florence)H-Index: 22
#2Federica Cherchi (UniFI: University of Florence)H-Index: 6
Last. Anna Maria Pugliese (UniFI: University of Florence)H-Index: 26
view all 16 authors...
Abstract Oligodendrocytes are the only myelinating cells in the brain and differentiate from their progenitors (OPCs) throughout adult life. However, this process fails in demyelinating pathologies. Adenosine is emerging as an important player in OPC differentiation and we recently demonstrated that adenosine A2A receptors inhibit cell maturation by reducing voltage-dependent K+ currents. No data are available to date about the A2B receptor (A2BR) subtype. The bioactive lipid mediator sphingosin...
9 CitationsSource