Delphine Franssen
University of Liège
Internal medicineEndocrinologyG protein-coupled receptorAndrologyNeuroscienceReceptorChemistryEstrous cycleAMP-activated protein kinaseKisspeptinHypothalamusOvulationBisphenol AAMPKPuberty onsetEpigeneticsEndocrine systemFolliculogenesisBioinformaticsRegulatorHormoneMedicineBiologyCell biology
39Publications
12H-index
303Citations
Publications 41
Newest
#1Giuliana Pellegrino (university of lille)H-Index: 1
#2Marion Martin (university of lille)
Last. Vincent Prevot (university of lille)H-Index: 60
view all 22 authors...
Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Here, we show that rodent GnRH neurons use a prostaglandin D2 receptor DP1 signaling mechanism during infancy to recruit newborn astrocytes that ‘escort’ them into adulthood, and that the impairment of postnatal hypothalamic gliogenesis markedly alters ...
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#1David Lopez-Rodriguez (University of Liège)H-Index: 3
#2Delphine Franssen (University of Liège)H-Index: 12
Last. Anne-Simone Parent (University of Liège)H-Index: 24
view all 4 authors...
Sexual maturation in humans is characterized by a unique individual variability. Pubertal onset is a highly heritable polygenic trait but it is also affected by environmental factors such as obesity or endocrine disrupting chemicals. The last 30 years have been marked by a constant secular trend toward earlier age at onset of puberty in girls and boys around the world. More recent data, although more disputed, suggest an increased incidence in idiopathic central precocious puberty. Such trends p...
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#1David Lopez-Rodriguez (University of Liège)H-Index: 3
#2Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 6
Last. Ezio Tirelli (University of Liège)H-Index: 24
view all 13 authors...
BACKGROUND The effects of endocrine-disrupting chemicals (EDCs) on fertility and reproductive development represent a rising concern in modern societies. Although the neuroendocrine control of sexual maturation is a major target of EDCs, little is known about the potential role of the hypothalamus in puberty and ovulation disruption transmitted across generations. OBJECTIVES We hypothesized that developmental exposure to an environmentally relevant dose of EDC mixture could induce multi- and/or ...
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#1Julie Boberg (DTU: Technical University of Denmark)H-Index: 27
#2Hanna Katarina Lilith Johansson (DTU: Technical University of Denmark)H-Index: 7
Last. Terje Svingen (DTU: Technical University of Denmark)H-Index: 24
view all 8 authors...
Disrupted ovarian development induced by chemical exposure may impair fertility later in life. Since androgens are essential for early ovarian development, we speculated that perinatal exposure to a binary mixture of the known anti-androgens DEHP and procymidone could alter steroid synthesis, disrupt ovarian follicle recruitment and ultimately maturation in female rat offspring. Wistar rat dams were exposed by oral gavage from gestation day 7 to postnatatal day 22 to two mixture doses known to a...
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Tachykinin (TAC) signaling is an important element in the central control of reproduction. TAC family is mainly composed of substance P (SP), neurokinin A (NKA) and NKB, which bind preferentially t...
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#1Delphine FranssenH-Index: 12
#2Terje SvingenH-Index: 24
Last. Anne-Simone ParentH-Index: 24
view all 6 authors...
The average age for pubertal onset in girls has declined over recent decades. Epidemiological studies in humans and experimental studies in animals suggest a causal role for Endocrine Disrupting Chemicals (EDCs) that are present in our environment. Of concern, current testing and screening regimens are inadequate in identifying EDCs that may affect pubertal maturation, not least because they do not consider early-life exposure. Also, the causal relationship between EDC exposure and pubertal timi...
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#1David Lopez-Rodriguez (University of Liège)H-Index: 3
#2Delphine Franssen (University of Liège)H-Index: 12
Last. Anne-Simone Parent (University of Liège)H-Index: 24
view all 5 authors...
The onset of puberty and the female ovulatory cycle are important developmental milestones of the reproductive system. These processes are controlled by a tightly organized network of neurotransmitters and neuropeptides, as well as genetic, epigenetic and hormonal factors, which ultimately drive the pulsatile secretion of gonadotropin-releasing hormone. They also strongly depend on organizational processes that take place during fetal and early postnatal life. Therefore, exposure to environmenta...
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Abstract Background Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, master elements and final output pathway for the brain control of reproduction, directly or indirectly receive and integrate multiple metabolic cues to regulate reproductive function. Yet, the molecular underpinnings of such phenomenon remain largely unfolded. AMP-activated protein kinase (AMPK), the fundamental cellular sensor that becomes activated in conditions of energy deficit, has been re...
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#1Hanna Katarina Lilith Johansson (DTU: Technical University of Denmark)H-Index: 7
#2Pauliina Damdimopoulou (Karolinska University Hospital)H-Index: 19
Last. Terje Svingen (DTU: Technical University of Denmark)H-Index: 24
view all 20 authors...
Modern living challenges female reproductive health. We are witnessing a rise in reproductive disorders and drop in birth rates across the world. The reasons for these manifestations are multifaceted and most likely include continuous exposure to an ever-increasing number of chemicals. The cause–effect relationships between chemical exposure and female reproductive disorders, however, have proven problematic to determine. This has made it difficult to assess the risks chemical exposures pose to ...
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#1David Lopez Rodriguez (University of Liège)H-Index: 1
#2Carlos F. Aylwin (Oregon National Primate Research Center)H-Index: 6
Last. Anne-Simone Parent (University of Liège)H-Index: 24
view all 13 authors...
Female reproductive development and maternal behavior are two intertwined phenotypes centrally controlled by the hypothalamus. Endocrine disrupting chemicals (EDC) can alter these processes especially when animals are exposed during development. We propose the concept that developmental exposure to a low environmentally relevant dose of EDC mixture induces a transgenerational alteration of female rat pubertal timing and ovarian physiology throughout epigenetic reprograming of hypothalamic Kiss1,...
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