Julio Rosenstock
University of Texas Southwestern Medical Center
Internal medicineEndocrinologyRandomized controlled trialAdverse effectPlaceboType 2 diabetesPostprandialInsulinInsulin glargineMetforminGlycemicHypoglycemiaType 1 diabetesType 2 Diabetes MellitusWeight lossDiabetes mellitusMedicineGastroenterology
Publications 452
Basal insulin treatment is indispensable for patients with type 1 diabetes and often required by many with type 2 diabetes. Incremental advances lengthening the duration of action of insulin analogs and reducing pharmacodynamic variability have resulted in truly once-daily, long-acting basal insulin analogs. In the quest for better basal insulins to facilitate improvements in glycemic control and long-term outcomes, the driving need is to remove barriers delaying timely initiation of basal insul...
#1Carolyn S.P. Lam (NUS: National University of Singapore)H-Index: 80
#2Chinthanie Ramasundarahettige (Population Health Research Institute)H-Index: 9
Last. Hertzel C. Gerstein (Population Health Research Institute)H-Index: 115
view all 12 authors...
Background: Sodium-glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) both reduce cardiovascular (CV) events among patients with type 2 diabetes. However, no CV outcome trial has evaluated the long-term effects of their combined use. The AMPLITUDE-O trial reported that once weekly injections of the GLP-1 RA efpeglenatide (vs. placebo) reduced major adverse cardiovascular events (MACE); MACE, coronary revascularization or unstable angina hospital...
I thank Dr. Marathe and coauthors, who are part of the superb team of Michael Horowitz and Karen Jones, world-renowned top experts in gastric emptying (1), for recognizing the clinical value of our albiglutide switch study (HARMONY 8), which provided proof of concept for the benefits of using a weekly glucagon-like peptide 1 receptor agonist (GLP-1RA) to simplify an intensive multiple-insulin regimen in patients with long-standing type 2 diabetes previously on basal-bolus insulin (2). We clearly...
#1Ronald GoldenbergH-Index: 24
#2Vanita R. ArodaH-Index: 35
Last. Melanie J. DaviesH-Index: 98
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#1Stefano Del Prato (UniPi: University of Pisa)H-Index: 72
#2Steven E. Kahn (UW: University of Washington)H-Index: 127
Last. Robert J. Heine (Eli Lilly and Company)H-Index: 22
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Summary null null Background null We aimed to assess efficacy and safety, with a special focus on cardiovascular safety, of the novel dual GIP and GLP-1 receptor agonist tirzepatide versus insulin glargine in adults with type 2 diabetes and high cardiovascular risk inadequately controlled on oral glucose-lowering medications. null null null Methods null This open-label, parallel-group, phase 3 study was done in 187 sites in 14 countries on five continents. Eligible participants, aged 18 years or...
#1Melanie J. Davies (University of Leicester)H-Index: 98
#2Julio RosenstockH-Index: 103
Last. Neil SkolnikH-Index: 8
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AIMS To assess the efficacy and safety of iGlarLixi (the titratable fixed-ratio combination of insulin glargine 100 U/mL [iGlar] plus lixisenatide [Lixi]), in adults with type 2 diabetes (T2D) with glycated haemoglobin (HbA1c) levels ≥8% (≥64 mmol/mol). MATERIALS AND METHODS The LixiLan-O study (NCT02058147) compared iGlarLixi with iGlar or Lixi in adults with T2D inadequately controlled on metformin ± a second oral antidiabetes drug (OAD). This exploratory analysis evaluated the LixiLan-O subgr...
#1David Z.I. Cherney (UHN: University Health Network)H-Index: 47
#2Petter Bjornstad (Anschutz Medical Campus)H-Index: 27
Last. Nima Soleymanlou (Boehringer Ingelheim)H-Index: 12
view all 7 authors...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors lower risk of cardiovascular and kidney events in people with type 2 diabetes. In the empagliflozin in type 1 diabetes clinical program (Empagliflozin as Adjunctive to inSulin thErapy [EASE]), glycemic control, body weight, and BP improved with
#1David Z.I. Cherney (U of T: University of Toronto)H-Index: 47
#2Ele FerranniniH-Index: 101
Last. Rajiv Agarwal (IU: Indiana University)H-Index: 85
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AIMS To assess the efficacy and safety of sotagliflozin, a dual inhibitor of sodium-glucose cotransporter-1 and -2, in adults with type 2 diabetes (T2D) and stage 4 chronic kidney disease (CKD4). MATERIALS AND METHODS This 52-week, phase 3, randomized (1:1:1), placebo-controlled trial evaluated sotagliflozin 200 mg and sotagliflozin 400 mg once daily in 277 patients with T2D and estimated glomerular filtration rate (eGFR) 15 to 30 mL/min/1.73 m2 . The primary endpoint was glycated haemoglobin (H...
#1Naveed Sattar (BHF: British Heart Foundation)H-Index: 174
#2Matthew M.Y. Lee (BHF: British Heart Foundation)H-Index: 11
Last. Richard E. Pratley (Translational Research Institute)H-Index: 23
view all 12 authors...
Summary null null Background null GLP-1 receptor agonists reduce major adverse cardiovascular events (MACE) in patients with type 2 diabetes. However, uncertainty regarding kidney outcomes persists and whether benefits extend to exendin-4-based GLP-1 receptor remains uncertain. We aimed to meta-analyse the most up-to-date evidence on the cardiovascular benefits and risks of GLP-1 receptor agonists from outcome trials in patients with type 2 diabetes. null null null Methods null We did a meta-ana...
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