Jorge D. Machicado
University of Pittsburgh
EpidemiologyInternal medicineRadiologyEtiologySurgeryPathologyIntensive care medicinePhysical therapyPediatricsProspective cohort studyPancreatitisAcute pancreatitisInflammatory bowel diseaseIrritable bowel syndromeMEDLINEPopulationIn patientMedicineCohortComplicationGastroenterology
117Publications
13H-index
515Citations
Publications 114
Newest
#1Ellyn K. Dunbar (University of Pittsburgh)H-Index: 1
#2Phil J. Greer (University of Pittsburgh)H-Index: 22
Last. Nalini M. GudaH-Index: 19
view all 21 authors...
INTRODUCTION Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are progressive inflammatory syndromes with variable features. Pain is the primary feature that contributes to low physical and mental quality of life with a third of patients reporting severe pain. Pain experience is worsened by depression. Here, we tested the hypothesis that genetic risk of the psychiatric conditions of anxiety and post-traumatic stress disorder (PTSD) is associated with pain in CP and RAP + CP subje...
Source
#1Jorge D. Machicado (Mayo Clinic)H-Index: 13
#2Wei-Lun Chao (OSU: Ohio State University)H-Index: 20
Last. Somashekar G. Krishna (The Ohio State University Wexner Medical Center)H-Index: 21
view all 18 authors...
Abstract Background and Aims EUS-guided needle-based confocal laser endomicroscopy (EUS-nCLE) can differentiate high-grade dysplasia/adenocarcinoma (HGD-Ca) in intraductal papillary mucinous neoplasms (IPMNs) but requires manual interpretation. We sought to derive predictive computer-aided diagnosis (CAD) and artificial intelligence (AI) algorithms to facilitate accurate diagnosis and risk stratification of IPMNs. Methods A post-hoc analysis of a single-center prospective study evaluating EUS-nC...
3 CitationsSource
#1Jorge D. MachicadoH-Index: 13
#2Dhiraj YadavH-Index: 52
Source
#1Filippos Koutroumpakis (University of Pittsburgh)H-Index: 1
#2Anna E. Phillips (University of Pittsburgh)H-Index: 5
Last. David G. Binion (University of Pittsburgh)H-Index: 59
view all 21 authors...
BACKGROUND Immunoglobulin G subclass 4 (IgG4) is hypothesized to play an immunomodulatory role, downregulating humoral immune responses. The role of this anti-inflammatory molecule in inflammatory bowel disease (IBD) has not been fully characterized. We sought to define alterations in serum IgG4 in patients with IBD and their association with multiyear disease severity. METHODS We analyzed metadata derived from curated electronic health records from consented patients with IBD prospectively foll...
1 CitationsSource
#1Jorge D. MachicadoH-Index: 13
#2Bertrand NapoleonH-Index: 28
Last. Somashekar G. KrishnaH-Index: 21
view all 17 authors...
Source
#1Jorge D. MachicadoH-Index: 13
#2Rawad MounzerH-Index: 15
Last. Georgios I. PapachristouH-Index: 49
view all 11 authors...
Source
#1Jorge D. Machicado (Mayo Clinic)H-Index: 13
#2Bertrand NapoleonH-Index: 28
Last. Somashekar G. Krishna (OSU: Ohio State University)H-Index: 21
view all 17 authors...
Source
#1Jorge D. Machicado (Mayo Clinic)H-Index: 13
#2Amir Gougol (University of Pittsburgh)H-Index: 6
Last. Georgios I. Papachristou (University of Pittsburgh)H-Index: 49
view all 31 authors...
BACKGROUND Persistent organ failure (POF) is the strongest determinant of mortality in acute pancreatitis (AP). There is a paucity of data regarding the impact of different POF attributes on mortality and the role of different characteristics of systemic inflammatory response syndrome (SIRS) in the risk of developing POF. OBJECTIVE We aimed to assess the association of POF dynamic features with mortality and SIRS characteristics with POF. METHODS We studied 1544 AP subjects prospectively enrolle...
Source
#1Pedram Paragomi (University of Pittsburgh)H-Index: 11
#2Marie Tuft (University of Pittsburgh)H-Index: 4
Last. Georgios I. Papachristou (OSU: Ohio State University)H-Index: 49
view all 23 authors...
BACKGROUND AND AIM The primary aim was to validate the Pancreatitis Activity Scoring System (PASS) in a multicenter prospectively ascertained acute pancreatitis (AP) cohort. Second, we investigated the association of early PASS trajectories with disease severity and length of hospital stay (LOS). METHODS Data were prospectively collected through the APPRENTICE consortium (2015-2018). AP severity was categorized based on revised Atlanta classification. Delta PASS (ΔPASS) was calculated by subtrac...
Source
#1Pedram Paragomi (University of Pittsburgh)H-Index: 11
#2Anna E. Phillips (University of Pittsburgh)H-Index: 5
Last. Georgios I. Papachristou (OSU: Ohio State University)H-Index: 49
view all 13 authors...
OBJECTIVES We describe the methodology of Post-Acute Pancreatitis Pancreatic Exocrine Insufficiency (PAPPEI), a prospective, observational, multicenter cohort study. The objectives of PAPPEI are to estimate the incidence rate of post-acute pancreatitis (AP) pancreatic exocrine insufficiency (PEI), define factors that determine the development of post-AP PEI, and evaluate the impact of post-AP PEI on nutritional status and quality of life. METHODS Enrollment started in June 2017 in 3 expert acade...
Source