Michal Kouril
Cincinnati Children's Hospital Medical Center
Discrete mathematicsMachine learningDistributed computingHeuristicsArtificial intelligenceBacktrackingPsychologyParallel computingCognitive psychologyProgramming languageInteroperabilityOnline research methodsNatural language processingDosingSoftwareMEDLINEImplicit-association testVan der Waerden numberR packageImplicit biasMathematicsVisualizationComputer scienceSource codeMedical emergencyClinical decision support systemInteractive visualizationSpeedupBoolean satisfiability problemPropositional calculusComputational biologyMedicineDrug discoveryAnalyticsTheoretical computer scienceMessage passingUser interface
Publications 41
#1Alexander Thorman (UC: University of Cincinnati)H-Index: 2
#2James Reigle (UC: University of Cincinnati)H-Index: 2
Last. Jarek MellerH-Index: 8
view all 18 authors...
Abstract The development of targeted treatment options for precision medicine is hampered by a slow and costly process of drug screening. While small molecule docking simulations are often applied in conjunction with cheminformatic methods to reduce the number of candidate molecules to be tested experimentally, the current approaches suffer from high false positive rates and are computationally expensive. Here, we present a novel in silico approach for drug discovery and repurposing, dubbed conn...
1 CitationsSource
#1Marcin Pilarczyk (UC: University of Cincinnati)H-Index: 7
#2Mehdi Fazel Najafabadi (UC: University of Cincinnati)H-Index: 2
Last. Mario MedvedovicH-Index: 49
view all 25 authors...
iLINCS (http://ilincs.org) is an integrative web-based platform for analysis of omics data and signatures of cellular perturbations. The portal facilitates analysis of user-submitted omics signatures of diseases and cellular perturbations in the context of a large compendium of pre-computed signatures (>200,000), as well as mining and re-analysis of the large collection of omics datasets (>10,000), pre-computed signatures and their connections. Analytics workflows driven by user-friendly interfa...
21 CitationsSource
#1Behrouz Shamsaei (University of Cincinnati Academic Health Center)H-Index: 6
#2Szymon Chojnacki (University of Cincinnati Academic Health Center)H-Index: 1
Last. Jarek Meller (UC: University of Cincinnati)H-Index: 8
view all 22 authors...
Rapid progress in proteomics and large-scale profiling of biological systems at the protein level necessitates the continued development of efficient computational tools for the analysis and interpretation of proteomics data. Here, we present the piNET server that facilitates integrated annotation, analysis and visualization of quantitative proteomics data, with emphasis on PTM networks and integration with the LINCS library of chemical and genetic perturbation signatures in order to provide fur...
5 CitationsSource
#1Benjamin D. Wissel (University of Cincinnati Academic Health Center)H-Index: 7
#2P J Van Camp (University of Cincinnati Academic Health Center)H-Index: 1
Last. Judith W. DexheimerH-Index: 15
view all 8 authors...
OBJECTIVE: To create an online resource that informs the public of COVID-19 outbreaks in their area. MATERIALS AND METHODS: This R Shiny application aggregates data from multiple resources that track COVID-19 and visualizes them through an interactive, online dashboard. RESULTS: The web resource, called the COVID-19 Watcher, can be accessed at https://covid19watcher.research.cchmc.org/. It displays COVID-19 data from every county and 188 metropolitan areas in the U.S. Features include rankings o...
31 CitationsSource
#1P. J. Van Camp (UC: University of Cincinnati)H-Index: 1
#2Eric S. KirkendallH-Index: 18
Last. Judith W. Dexheimer (Cincinnati Children's Hospital Medical Center)H-Index: 15
view all 8 authors...
: Frequently overridden alerts in the electronic health record can highlight alerts that may need revision. This method is a way of fine-tuning clinical decision support. We evaluated the feasibility of a complementary, yet different method that directly involved pediatric emergency department (PED) providers in identifying additional medication alerts that were potentially incorrect or intrusive. We then evaluated the effect subsequent resulting modifications had on alert salience. METHODS: We ...
1 CitationsSource
#1Alexander Thorman (UC: University of Cincinnati)H-Index: 2
#2James Reigle (UC: University of Cincinnati)H-Index: 2
Last. Jarek Meller (UC: University of Cincinnati)H-Index: 8
view all 10 authors...
#1Thomas P. Carpenter (SPU: Seattle Pacific University)H-Index: 9
#2Ruth Pogacar (U of C: University of Calgary)H-Index: 5
Last. Aleksandr Chakroff (Harvard University)H-Index: 4
view all 8 authors...
The implicit association test (IAT) is widely used in psychology. Unfortunately, the IAT cannot be run within online surveys, requiring researchers who conduct online surveys to rely on third-party tools. We introduce a novel method for constructing IATs using online survey software (Qualtrics); we then empirically assess its validity. Study 1 (student n = 239) revealed good psychometric properties, expected IAT effects, and expected correlations with explicit measures for survey-software IATs. ...
36 CitationsSource
#1Naim Al Mahi (UC: University of Cincinnati)H-Index: 5
#2Mehdi Fazel Najafabadi (UC: University of Cincinnati)H-Index: 2
Last. Mario Medvedovic (UC: University of Cincinnati)H-Index: 49
view all 5 authors...
The vast amount of RNA-seq data deposited in Gene Expression Omnibus (GEO) and Sequence Read Archive (SRA) is still a grossly underutilized resource for biomedical research. To remove technical roadblocks for reusing these data, we have developed a web-application GREIN (GEO RNA-seq Experiments Interactive Navigator) which provides user-friendly interfaces to manipulate and analyze GEO RNA-seq data. GREIN is powered by the back-end computational pipeline for uniform processing of RNA-seq data an...
34 CitationsSource
#1Ruth Pogacar (U of C: University of Calgary)H-Index: 5
#2Thomas P. Carpenter (SPU: Seattle Pacific University)H-Index: 9
Last. Michal Kouril (Cincinnati Children's Hospital Medical Center)H-Index: 14
view all 4 authors...
#2Michal KourilH-Index: 14
Last. Naomi IsenbergH-Index: 3
view all 8 authors...