Daisuke Uta
University of Toyama
AnatomyExcitatory postsynaptic potentialEndocrinologyPatch clampNociceptionTransient receptor potential channelTRPV1NeuroscienceReceptorInhibitory postsynaptic potentialChemistryPostsynaptic potentialNeurotransmissionIn vivoNaftopidilAllodyniaSpinal cordMedicineBiologyPharmacology
53Publications
10H-index
321Citations
Publications 52
Newest
#1Sandra Derouiche (Graduate University for Advanced Studies)
#2Tianbang LiH-Index: 4
Last. Makoto TominagaH-Index: 53
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ABSTRACT Arthropods are the largest group of living organisms and among them, mosquitoes spread parasites and viruses causing deathly diseases. They can spread easily these pathogens because of their painless skin piercing. Although the lack of pain is mainly due to the thinness of their fascicle, it is possible that mosquito saliva, which is discharged during their piercing, might contribute. If mosquito saliva contains antinociceptive substances, it should act on the sensory neurons innervatin...
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#1Norikazu Kiguchi (Wakayama Medical University)H-Index: 24
#2Yohji Fukazawa (Kansai University)H-Index: 14
Last. Shiroh Kishioka (Takarazuka University)H-Index: 1
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Several lines of evidence have clarified that the key transmission pathways of itching sensation travel from the periphery to the central nervous system (CNS). Despite the functional significance of gastrin-releasing peptide (GRP) and its cognate receptor in the itch processing mechanism in the spinal dorsal horn (SDH), the roles of GRP-expressing (GRP+ ) neurons in different regions remain unclear. This study aimed to determine whether GRP+ neurons in the CNS directly modulated itch processing....
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The spinal ejaculation generator (SEG) is located in the central gray (lamina X) of the rat lumbar spinal cord and plays a pivotal role in the ejaculatory reflex. We recently reported that SEG neurons express the oxytocin receptor and are activated by oxytocin projections from the paraventricular nucleus of hypothalamus (PVH). However, it is unknown whether the SEG responds to oxytocin in vivo. In this study, we analyzed the characteristics of the brain–spinal cord neural circuit that controls m...
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#1Takumi Oti (Kanagawa University)H-Index: 6
#2Keita Satoh (Okayama University)H-Index: 7
Last. Hirotaka Sakamoto (University of Oxford)H-Index: 28
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Summary Oxytocinergic neurons in the paraventricular nucleus of the hypothalamus that project to extrahypothalamic brain areas and the lumbar spinal cord play an important role in the control of erectile function and male sexual behavior in mammals. The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord is an important component of the neural circuits that control penile reflexes in rats, circuits that are commonly referred to as the “spinal ejaculation generator (SEG).” We ha...
3 CitationsSource
#1Genki Hiramatsu (University of Toyama)
#2Daisuke Uta (University of Toyama)H-Index: 10
Last. Toshiaki Kume (University of Toyama)H-Index: 40
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Abstract Activated microglia induce brain inflammation and neuronal death. Panaxytriol, (3R,9R,10R)-Heptadec-1-en-4,6-diyne-3,9,10-triol), is a component of Panax ginseng C. A. Meyer extracts and activates the Nrf2-ARE signaling pathway. However, little is known about its effects on activated microglia in the brain. In this study, we investigated the effect of panaxytriol on lipopolysaccharide (LPS)-induced activated microglia in BV-2 cells. Panaxytriol suppressed LPS-induced NO production and i...
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#1Daisuke UtaH-Index: 10
#2Kohei KogaH-Index: 21
Last. Megumu YoshimuraH-Index: 40
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BACKGROUND Although the widely used single L-enantiomers of local anesthetics have less toxic effects on the cardiovascular and central nervous systems, the mechanisms mediating their antinociceptive actions are not well understood. The authors hypothesized that significant differences in the ion channel blocking abilities of the enantiomers of bupivacaine would be identified. METHODS The authors performed electrophysiologic analysis on rat dorsal root ganglion neurons in vitro and on spinal tra...
1 CitationsSource
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#2Atsushi Doi (Kumamoto Health Science University)H-Index: 31
Last. Min Chul Shin (Kumamoto Health Science University)H-Index: 27
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#1Daisuke Uta (Kyushu University)H-Index: 6
#1Daisuke Uta (Kyushu University)H-Index: 10
Last. Megumu Yoshimura (Kyushu University)H-Index: 40
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PURPOSE Alpha1-adrenoceptors participate in improving storage symptoms of male lower urinary tract symptoms (LUTS). However, the mechanism of action of these compounds remains unclear. To clarify the mechanism of the α1-adrenoceptor antagonists, the amplitude of miniature excitatory postsynaptic currents (mEPSCs) was analyzed in the lumbosacral spinal cord in rats. METHODS Male adult Sprague-Dawley rats were used. Blind whole-cell patch-clamp recordings were performed on substantia gelatinosa (S...
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#1Daisuke Uta (Kyushu University)H-Index: 10
#1Daisuke Uta (Kyushu University)H-Index: 6
Last. Megumu Yoshimura (Kyushu University)H-Index: 40
view all 3 authors...
PURPOSE Alpha1-adrenoceptors participate in improving storage symptoms of male lower urinary tract symptoms. However, the mechanism of action of these compounds remains unclear. The goal of the present study was to clarify the effect of α1- adrenoceptor antagonists on γ-aminobutyric acid (GABA)/glycine-mediated outward currents of the inhibitory postsynaptic current (IPSC) in substantia gelatinosa (SG) neurons from the lumbosacral spinal cord in rats. METHODS Male adult Sprague-Dawley rats were ...
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