Natalie Prinzi
University of Milan
CancerInternal medicinePathologyOncologyAdverse effectAurora inhibitorHazard ratioSomatostatinChemotherapyMerkel cell carcinomaNeuroendocrine tumorsDiseaseLanreotideEverolimusThyroid cancerMetforminProgression-free survivalPopulationCell cycleThyroid carcinomaGastro entero pancreaticIn patientWell differentiatedCancer researchRadiation therapyThyroidMedicineBiologyGastroenterology
Publications 78
#1Sandra P. D'Angelo (Cornell University)H-Index: 39
#2Celeste Lebbe (University of Paris)H-Index: 81
Last. Felix Kiecker (Charité)H-Index: 14
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Background null Avelumab (anti-programmed death ligand 1 (PD-L1)) is approved in multiple countries for the treatment of metastatic Merkel cell carcinoma (mMCC), a rare and aggressive skin cancer. We report efficacy and safety data and exploratory biomarker analyses from a cohort of patients with mMCC treated with first-line avelumab in a phase II trial. null Methods null Patients with treatment-naive mMCC received avelumab 10 mg/kg intravenously every 2 weeks. The primary endpoint was durable r...
#1Sara PuscedduH-Index: 18
#2Antonio Facciorusso (University of Foggia)H-Index: 19
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Although combination therapy is not recommended in patients with gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs), this strategy is widely used in clinical practice. This network meta-analysis of randomized trials evaluates targeted therapies and somatostatin analogues in GEP advanced NETs, either alone or in combination, comparing the efficacy of different single or combined treatment strategies in terms of progression-free survival (PFS). Interventions were grouped as analogues, eve...
#1Ketevani Kankava (Tbilisi State Medical University)H-Index: 3
#2Patrick Maisonneuve (IEO: European Institute of Oncology)H-Index: 134
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Updates in classification of gastro-entero-pancreatic neuroendocrine neoplasms better reflect the biological characteristics of these tumours. In the present study, we analysed the characteristics of neuroendocrine tumours that could aid in a more precise stratification of risk groups. In addition, we have highlighted the importance of grade (re)assessment based on investigation of secondary tumour lesions. Two hundred and sixty-four cases of neuroendocrine tumours of gastro-entero-pancreatic or...
#1Martina TorchioH-Index: 8
#2Laura CattaneoH-Index: 12
Last. Giulia Bertino (UNIPV: University of Pavia)H-Index: 19
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This case report shows, for the first time, a patient experiencing a complete response after one dose of avelumab following extensive disease progression with prior electrochemotherapy (ECT) treatment. We suggest that ECT may help to establish a tumor microenvironment favorable to immunotherapy. Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with seldom durable chemotherapy responses. ECT has recently emerged as a potential treatment option for several malignancies, including MCC...
#1Natalie PrinziH-Index: 12
#2Roberta Elisa Rossi (University of Milan)H-Index: 26
Last. Sara PuscedduH-Index: 18
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Neuroendocrine neoplasms of the lung represent about 20% to 30% of all neuroendocrine tumors. On the basis of clinical and pathologic characteristics, 2 different categories of tumors may be defined: poorly differentiated neuroendocrine neoplasms, characterized by a high rate of recurrences and poor prognosis, and well-differentiated neuroendocrine neoplasms (typical carcinoids and atypical carcinoids), which generally display an indolent course. Lung carcinoids represent only 1% to 5% of all lu...
#1Massimo MilioneH-Index: 31
#2Patrick MaisonneuveH-Index: 134
Last. Carlo CapellaH-Index: 89
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BACKGROUND: Little information is available concerning prognostic factors of bronchopulmonary large cell neuroendocrine carcinomas (BP-LCNECs) and even less is known about combined LCNECs (Co-LCNECs). We investigated whether an integrated morphological, immunohistochemical and molecular approach could be used for their prognostic evaluation. METHODS: Morphological (including combined features), proliferative (mitotic count/Ki-67 index), immunohistochemical (napsin A, p-40, TTF-1, CD44, OTP, SSTR...
5 CitationsSource
#1Giovanni CentonzeH-Index: 11
#2Vincenzo LaganoH-Index: 1
Last. Massimo MilioneH-Index: 31
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High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with proliferative activity indexes as mitotic count (MC) >20 mitoses/10 HPF and Ki-67 >20%. At present, no specific therapy for H-NENs exists and the several evidences of microenvironment involvement in their pathogenesis pave the way for tailored therapies. Forty-five consecutive cases, with available information about T-cell, immune, and...
1 CitationsSource
#1Ketevani KankavaH-Index: 3
#2Patrick MaisonneuveH-Index: 134
view all 15 authors...
#1Luigi BarreaH-Index: 28
#2Marco Gallo (UNITO: University of Turin)H-Index: 16
Last. Roberto BaldelliH-Index: 30
view all 12 authors...
AbstractThe incidence of differentiated thyroid cancer has been increasing in the last decades all over the world. Such a steady growth cannot be entirely attributable to more intensive thyroid nod...
14 CitationsSource