Francesca Maestrelli
University of Florence
Nuclear chemistryDissolution testingSolubilityFourier transform infrared spectroscopyOrganic chemistryBioavailabilityAqueous solutionChemistryIn vivoInclusion compoundCyclodextrinChitosanDrugDifferential scanning calorimetryChemical engineeringChromatographyPermeationTernary operationDosage formDissolution
75Publications
27H-index
1,743Citations
Publications 76
Newest
#1Damiano CirriH-Index: 9
#2Ida LandiniH-Index: 21
Last. Luigi MessoriH-Index: 57
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Auranofin (AF) and its iodido analog, i.e., Au(PEt3) I (AFI), were reported to exhibit very promising anticancer properties both in vitro and in vivo. However, both these gold compounds have a scarce aqueous solubility that hampers their pharmaceutical use. Here, we explore whether encapsulation of these metallodrugs inside hydroxypropyl-beta–cyclodextrin (HPβ–CD) may lead to an improved biopharmaceutical profile for the resulting adducts. Phase solubility studies, performed at 25 °C in an aqueo...
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#1Paola MuraH-Index: 50
Last. Marzia CirriH-Index: 33
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The aim of this study was the optimization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in terms of physicochemical and biopharmaceutical properties, to develop effective and stable aqueous liquid formulations of hydrochlorothiazide, suitable for paediatric therapy, overcoming its low-solubility and poor-stability problems. Based on solubility studies, Precirol® ATO5 and Transcutol® HP were used as solid and liquid lipids, respectively. The effect of different surfa...
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#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Metronidazole is the drug of choice in the treatment of bacterial vaginosis, but the oral therapy can induce several collateral effects. Aim of this work was the development of a vaginal multiparticulate system loaded with metronidazole able to improve its residence time allowing a complete drug release. Several kinds of MS were prepared using chitosan dissolved in different organic acids or alginate coated with chitosan. FTIR and DSC analyses were performed to study the interactions be...
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#1Emanuela BerrinoH-Index: 7
#2Simone CarradoriH-Index: 34
Last. Marialucia GalloriniH-Index: 10
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Low concentrations of carbon monoxide (CO) were reported to exhibit anti-inflammatory effects when administered in cells by suitable chemotypes such as CO releasing molecules (CO-RMs). In addition, the pH-modulating abilities of specific carbonic anhydrase isoforms played a crucial role in different models of inflammation and neuropathic pain. Herein, we report a series of chemical hybrids consisting of a Carbonic Anhydrase (CA) inhibitor linked to a CO-RM tail (CAI/CO-RMs). All compounds and th...
1 CitationsSource
#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Hydrochlorothiazide (HCT) is widely used in pediatrics for hypertension management. Due to the lack of pediatric commercial forms, community or hospital pharmacies generally prepare HCT extemporaneous pediatric suspensions by dispersing in water a portion of a crushed tablet or the drug powder; however, any dose or stability control is usually done on these preparations. Obtaining stable HCT solutions is very challenging, due to its low water-solubility and pH-dependent degradation. The...
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#1Yasamin Soleimanian (IUT: Isfahan University of Technology)H-Index: 2
#2Sayed Amir Hossein Goli (IUT: Isfahan University of Technology)H-Index: 20
Last. Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
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The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for improving the oral delivery of β-sitosterol, a poorly water-soluble bioactive component with hypocholesterolemic activity. Two β-sitosterol formulations with different solid lipid compositions were prepared by melt emulsification, followed by the sonication technique, and the effect of storage conditions and simulated digestion on the physical, chemical and oxidative stability, bioaccessib...
1 CitationsSource
#1Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
#2Patrizia Rossi (UniFI: University of Florence)H-Index: 22
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Flufenamic acid is a nonsteroidal anti-inflammatory drug characterized by a low solubility and a variable oral bioavailability. Flufenamic acid is present in the commercial products in two polymorphic enantiotropic forms (Form I and III). Bioinequivalence was observed for commercial solid dosage forms due to the different dissolution rate of batches. Aim of this work is the full characterization of the solid state properties of flufenamic acid in order to evidence reasons of its variabl...
3 CitationsSource
#1Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
#2Marzia Cirri (UniFI: University of Florence)H-Index: 33
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Hydrochlorothiazide (HCT), a Biopharmaceutical Classification System (BCS) class IV drug, is characterized by low solubility and permeability, that negatively affect its oral bioavailability, reducing its therapeutic efficacy. The combined use of cyclodextrins (CDs) and nanoclays (NCs) recently proved to be a successful strategy in developing delivery systems able to merge the potential benefits of both carriers. In this work, several binary systems of CDs or NCs with the drug were obtained, usi...
5 CitationsSource
#1Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
#2Elisa Landucci (UniFI: University of Florence)H-Index: 17
Last. Cristina NativiH-Index: 25
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The transient receptor potential akyrin type-1 (TRPA1) is a non-selective cation channel playing a pivotal role in pain sensation and neurogenic inflammation. TRPA1 channels expressed in the central nervous system (CNS) have a critical role in the modulation of cortical spreading depression (CSD), which is a key pathophysiological basis of migraine pain. ADM_09 is a recently developed lipoic acid-based TRPA1 antagonist that is able to revert oxaliplatin-induced neuropathic pain and inflammatory ...
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#1Paola Mura (UniFI: University of Florence)H-Index: 50
#2Maurizio ValleriH-Index: 6
Last. Marzia Cirri (UniFI: University of Florence)H-Index: 33
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Abstract This work evaluated the suitability of various mesoporous silicas as carriers for developing an oral formulation endowed with improved dissolution properties of glibenclamide, hypoglycemic agent poorly water-soluble. The different silicas were examined for solid-state, morphology, and technological and physical-chemical properties (granulometry, specific surface area, wettability, water content, water activity, apparent density, flowability, compactability). A pairwise comparison allowe...
8 CitationsSource