Theresa A. Guise
University of Texas MD Anderson Cancer Center
Transforming growth factorCancerInternal medicineEndocrinologyPathologyOncologyBone remodelingOsteoclastOsteoporosisBone metastasisOsteoblastMetastasisProstate cancerOsteolysisCancer researchBreast cancerBone resorptionMedicineBiologyCancer cell
272Publications
47H-index
18.4kCitations
Publications 145
Newest
#1Nathan Handley (Thomas Jefferson University)H-Index: 7
#2Felix Y. Feng (UCSF: University of California, San Francisco)H-Index: 35
Last. Leonard G. Gomella (Thomas Jefferson University)H-Index: 79
view all 6 authors...
Androgen deprivation therapy, alone or in combination with androgen signaling inhibitors, is a treatment option for patients with advanced prostate cancer (PC). When making treatment decisions, health care providers must consider the long-term effects of treatment on the patient's overall health and well-being. Herein, we review the effects of these treatments on the musculoskeletal and cardiovascular systems, cognition, and fall risk, and provide management approaches for each. We also include ...
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#1Arif Hussain (University of Maryland Marlene and Stewart Greenebaum Cancer Center)H-Index: 26
#2Abhishek Tripathi (University of Oklahoma Health Sciences Center)H-Index: 4
Last. Theresa A. Guise (IU: Indiana University)H-Index: 47
view all 7 authors...
Background Osteoporosis is a skeletal disorder characterized by compromised bone strength, resulting in increased fracture risk. Patients with prostate cancer may have multiple risk factors contributing to bone fragility: advanced age, hypogonadism, and long-term use of androgen-deprivation therapy. Despite absence of metastatic disease, patients with nonmetastatic castrate-resistant prostate cancer receiving newer androgen receptor inhibitors can experience decreased bone mineral density. A sys...
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#1Yuki Nagata (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 2
#2Kazuaki Miyagawa (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 1
Last. Noriyoshi Kurihara (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 6
view all 10 authors...
Paget's disease (PD) is characterized by increased numbers of abnormal osteoclasts (OCLs) that drive exuberant bone formation, but the mechanisms responsible for the increased bone formation remain unclear. We previously reported that OCLs from 70% of PD patients express measles virus nucleocapsid protein (MVNP), and that transgenic mice with targeted expression of MVNP in OCLs (MVNP mice) develop bone lesions and abnormal OCLs characteristic of PD. In this report, we examined if OCL-derived sph...
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#1Tarah J. BallingerH-Index: 8
#2Ziyue LiuH-Index: 20
Last. Erik A. ImelH-Index: 31
view all 6 authors...
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#1Ruizhong WangH-Index: 3
#2Brijesh KumarH-Index: 5
Last. Harikrishna Nakshatri (IU: Indiana University)H-Index: 70
view all 16 authors...
Background Loss of skeletal muscle volume and resulting in functional limitations are poor prognostic markers in breast cancer patients. Several molecular defects in skeletal muscle including reduced MyoD levels and increased protein turn over due to enhanced proteosomal activity have been suggested as causes of skeletal muscle loss in cancer patients. However, it is unknown whether molecular defects in skeletal muscle are dependent on tumor etiology. Methods We characterized functional and mole...
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#4Carol H. Sampson (IU: Indiana University)H-Index: 4
Identification of medical countermeasures (MCM) to mitigate radiation damage and/or protect first responders is a compelling unmet medical need. The prostaglandin E2 (PGE2) analog, 16,16 dimethyl-PGE2 (dmPGE2), has shown efficacy as a radioprotectant and radiomitigator that can enhance hematopoiesis and ameliorate intestinal mucosal cell damage. In this study, we optimized the time of administration of dmPGE2 for protection and mitigation against mortality from the hematopoietic acute radiation ...
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#1Xin Yi (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 3
#2Laura E. WrightH-Index: 11
Last. William R. Thompson (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 64
view all 11 authors...
Exercise benefits the musculoskeletal system and reduces the effects of cancer. The effects of exercise are multifactorial, where metabolic changes and tissue adaptation influence outcomes. Mechanical signals, a principal component of exercise, are anabolic to the musculoskeletal system and restrict cancer progression. We examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of vibration. Low-magnitude, high-frequency vibr...
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#1Weidong Xu (U of C: University of Chicago)H-Index: 7
#3Zebin Hu (U of C: University of Chicago)H-Index: 9
Last. Prem Seth (U of C: University of Chicago)H-Index: 53
view all 15 authors...
: We report here the development of oncolytic adenoviruses (Ads) that have reduced toxicity, enhanced tumor tropism, produce strong antitumor response, and can overcome resistance to immune checkpoint inhibitor therapy in breast cancer. We have shown that LyP-1 receptor (p32) is highly expressed on the surface of breast cancer cells and tumors from cancer patients, and that increased stromal expression of TGFβ-1 is associated with triple negative breast cancer (TNBC) . Therefore, we constructed ...
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#1Michael J. Morris (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 70
#2Eva Corey (UW: University of Washington)H-Index: 53
Last. George Sgouros (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
view all 8 authors...
The targeted alpha therapy radium-223 (223Ra) can prolong survival in men with castration-resistant prostate cancer (CRPC) who have symptomatic bone metastases and no known visceral metastases. Preclinical studies demonstrate that 223Ra preferentially incorporates into newly formed bone matrix within osteoblastic metastatic lesions. The emitted high-energy alpha particles induce DNA double-strand breaks that might be irreparable and lead to cell death in nearby exposed tumour cells, osteoblasts ...
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#1Xin Yi (IU: Indiana University)H-Index: 3
#2Laura E. Wright (IU: Indiana University)H-Index: 11
Last. Theresa A. Guise (IU: Indiana University)H-Index: 47
view all 11 authors...
Exercise benefits the musculoskeletal system and reduces the effects of cancer. The beneficial effects of exercise are multifactorial, where metabolic changes and tissue adaptation influence outcomes. Mechanical signals, a principal component of exercise, are anabolic to the musculoskeletal system and restrict cancer progression. We examined the mechanisms through which cancer cells sense and respond to mechanical signals. Low-magnitude, high-frequency signals were applied to human breast cancer...
Source
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