Lauren E. Kokai
University of Pittsburgh
AnatomyInternal medicineEndocrinologyBiomedical engineeringNerve guidance conduitSoft tissueSurgeryPathologyCellRegeneration (biology)Adipose tissueChemistryParticle sizeMesenchymal stem cellAdipocyteWound healingStromal vascular fractionBreast reconstructionSciatic nerveStem cellFat graftingAutologous Fat GraftMedicineEpineurial repairCell biology
Publications 44
#1Xiaonan Yang (University of Pittsburgh)H-Index: 1
#2Jonathan P. Brower (University of Pittsburgh)H-Index: 1
Last. Jeffrey A. Gusenoff (University of Pittsburgh)H-Index: 21
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Background Many techniques and devices have been developed to improve small volume fat grafting efficiency and consistency for use in the operating room and outpatient procedure room. These methods require cumbersome or messy processing to remove excess oil and fluid from adipose graft. Objectives The aim of this study was to compare fat processing efficiency of a novel hand-held device, the Push-to-Spin (P2S™) system, to other common processing techniques and validate tissue quality after lipoa...
#1Asim Ejaz (University of Pittsburgh)H-Index: 6
#2Katherine S. Yang (University of Pittsburgh)H-Index: 20
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
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Background: Autologous fat transfer in the form of lipoaspirates for the reconstruction of the breast after breast cancer surgery is a commonly used procedure in plastic surgery. However, concerns regarding the oncologic risk of nutrient-rich fat tissue are widely debated. Previous studies have primarily focused on studying the interaction between adipose-derived stem cells (ASCs) and breast cancer cells. Methods: In this study, we performed a comprehensive analysis of the paracrine- and contact...
1 CitationsSource
#1Allison Schroeder (University of Pittsburgh)H-Index: 2
#2J. Peter Rubin (University of Pittsburgh)H-Index: 60
Last. Kentaro Onishi (University of Pittsburgh)H-Index: 8
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Musculoskeletal (MSK) injuries are among the most prevalent, disabling, and costly conditions that Americans face, affecting over half of those over 18 and nearly 75% of those over 65. Current treatments are largely palliative for many of these conditions and unmet needs have warranted the emergence of alternative treatments. Orthobiologics, such as adipose tissue derivatives (ATDs), are of high interest since they can be obtained in the office setting and their cellular components, including ad...
3 CitationsSource
#1Riccardo Schweizer (University of Pittsburgh)H-Index: 14
#2Matthias Waldner (University of Pittsburgh)H-Index: 6
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
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Background: Mesenchymal stromal cell (MSC)-based cytotherapies fuel the hope for reduction of chronic systemic immunosuppression in allotransplantation, and our group has previously shown this capability for both swine and human cells. MSCs harvested from distinct anatomical locations may have different behavior and lead to different outcomes in both preclinical research and human trials. To provide an effective reference for cell therapy studies, we compared human and porcine MSCs from omental ...
1 CitationsSource
#1Xiaonan YangH-Index: 1
#2Francesco M. EgroH-Index: 11
Last. Lauren E. KokaiH-Index: 14
view all 8 authors...
#1Lauren E. Kokai (University of Pittsburgh)H-Index: 14
#2Wesley N. Sivak (University of Pittsburgh)H-Index: 11
Last. J. Peter Rubin (University of Pittsburgh)H-Index: 60
view all 10 authors...
Biomaterials derived from human adipose extracellular matrix have shown promise in vitro and in animal studies as an off-the-shelf adipogenic matrix for sustained volume replacement. Herein, we report the results of a randomized prospective study conducted with allograft adipose matrix (AAM) grafted into the pannus of presurgical abdominoplasty patients 3 or 6 months before scheduled surgery. This is the first report of a longitudinal histologic analysis of AAM in clinical use. Methods: Ten heal...
3 CitationsSource
2 CitationsSource