Salvatore Sotgia
University of Sassari
AnalyteDetection limitInternal medicineEndocrinologyChemistryOxidative stressCOPDInflammationDerivatizationHomocysteineArginineCysteineAsymmetric dimethylarginineThiolCapillary electrophoresisElectrophoresisChromatographyGlutathioneBiochemistryMedicineBiology
144Publications
25H-index
1,900Citations
Publications 144
Newest
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Arduino A. Mangoni (Flinders Medical Centre)H-Index: 40
view all 4 authors...
Abstract null null Objectives null We conducted a systematic review and meta-analysis with meta-regression of creatine kinase-MB (CK-MB), a biomarker of myocardial injury, in COVID-19 patients. null null null Methods null We searched PubMed, Web of Science and Scopus, for studies published between January 2020 and January 2021 that reported CK-MB, COVID-19 severity and mortality (PROSPERO registration number: CRD42021239657). null null null Results null Fifty-five studies in 11,791 COVID-19 pati...
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#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Arduino A. Mangoni (Flinders University)H-Index: 40
view all 4 authors...
Alterations in cardiac biomarkers have been reported in patients with coronavirus disease 2019 (COVID-19) in relation to disease severity and mortality. We conducted a systematic review and meta-analysis with meta-regression of studies reporting B-type natriuretic peptide (BNP) or N-terminal proBNP (NT-proBNP) plasma concentrations in COVID-19. We searched PubMed, Web of Science, and Scopus, between January 2020 and 2021, for studies reporting BNP/NT-proBNP concentrations, measures of COVID-19 s...
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#1Salvatore SotgiaH-Index: 25
#2Alessandro G. FoisH-Index: 17
Last. Angelo ZinelluH-Index: 31
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This study aimed to review and critically appraise the current methodological issues undermining the suitability of the measurement of serum/plasma glutathione, both in the total and reduced form, as a measure of systemic oxidative stress in chronic obstructive pulmonary disease (COPD). Fourteen relevant articles published between 2001 and 2020, in 2003 subjects, 1111 COPD patients, and 892 controls, were reviewed. Nine studies, in 902 COPD patients and 660 controls, measured glutathione (GSH) i...
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#1Arduino A. Mangoni (Flinders Medical Centre)H-Index: 40
#2Sara Tommasi (Flinders Medical Centre)H-Index: 7
Last. Gian Luca Erre (University of Sassari)H-Index: 17
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Patients with rheumatoid arthritis (RA), a chronic and disabling autoimmune condition that is characterized by articular and extra-articular manifestations and a pro-inflammatory and pro-oxidant state, suffer from premature atherosclerosis and excessive cardiovascular disease burden. A key step in the pathogenesis of atherosclerosis is the impaired synthesis of the endogenous messenger nitric oxide (NO) by endothelial cells which, in turn, alters local homeostatic mechanisms and favors vascular ...
1 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Angelo Zinellu (University of Sassari)H-Index: 31
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The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled red...
1 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Andrea TarasH-Index: 1
Last. Luisa Bogliolo (University of Sassari)H-Index: 24
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The dependence of a stallion’s spermatozoa on oxidative phosphorylation for energy requirements results in an unconventional relationship between reactive oxygen species (ROS) production and fertility. In such a scenario, antioxidant activity must be finely controlled and not affect the essential functions of ROS. Some in vivo evidence suggests that the naturally occurring antioxidant ergothioneine (ERT) interferes with the critical roles of ROS/reactive nitrogen species (RNS) in pro-oxidant sta...
1 CitationsSource
#1Stefania BassuH-Index: 2
#2Angelo ZinelluH-Index: 31
Last. Gian Luca ErreH-Index: 17
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Previous studies have suggested that oxidative stress may heighten atherosclerotic burden in rheumatoid arthritis (RA), but direct evidence is lacking. Objective: To evaluate the relationship between established plasma oxidative stress biomarkers and peripheral endothelial dysfunction (ED), a marker of early atherosclerosis, in RA. Methods: Paroxonase-1 (PON-1), protein-SH (PSH), and malondialdehyde (MDA) were measured in 164 RA patient s and 100 age- and sex-matched healthy controls without pre...
1 CitationsSource
#1Gian Luca Erre (University of Sassari)H-Index: 17
#2Arduino A. Mangoni (Flinders Medical Centre)H-Index: 40
Last. Salvatore Sotgia (University of Sassari)H-Index: 25
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BACKGROUND The relationship between plasma arginine metabolites influencing vascular homeostasis and peripheral vasodilatory capacity in rheumatoid arthritis (RA) patients is not known. METHODS l-arginine (Arg), monomethyl-l-arginine (MMA), l-homoarginine (hArg), asymmetric dimethyl-l-arginine (ADMA), symmetric dimethyl-l-arginine, and l-citrulline (Cit) were measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) in 164 RA patients and 100 age- and sex-matched healthy controls wit...
1 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Elisabetta ZinelluH-Index: 16
Last. Pietro Pirina (University of Sassari)H-Index: 26
view all 11 authors...
It is amply reported that patients with chronic obstructive pulmonary disease (COPD) have increased risk of cardiovascular disease (CVD). Recent evidence suggests that COPD patients have elevated concentrations of plasma homocysteine (Hcy), a transsulfuration pathway analyte that is commonly regarded as a CVD risk factor. We comprehensively investigated the plasma concentrations of transsulfuration pathway analytes, and their relationship with markers of oxidative stress and inflammation, to ide...
5 CitationsSource
#1Salvatore Sotgia (University of Sassari)H-Index: 25
#2Alessandro G. Fois (University of Sassari)H-Index: 17
Last. Ciriaco Carru (University of Sassari)H-Index: 38
view all 7 authors...
Abstract A micellar electrokinetic capillary chromatographic method, a variant of capillary electrophoresis, was developed for the detection and measurement of pirfenidone and 5-carboxy-pirfenidone by direct injection of plasma from patients under treatment for idiopathic pulmonary fibrosis. To achieve the best separation a 35 mmol/L N-lauroylsarcosine sodium salt surfactant added with a 16 mmol/L sodium 1-heptanesulfonate solution was used as a running buffer. Analytes were eluted in a fairly s...
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